Abstract
Objectives: Tardive dyskinesia (TD) is a movement disorder that may develop as a side effect of antipsychotic medication. The aetiology underlying TD is unclear, but a number of mechanisms have been proposed. Methods: We investigated single-nucleotide polymorphisms (SNPs) in the genes coding for neuregulin-1 and erbB-4 receptor in our sample of 153 European schizophrenia patients for possible association with TD. Results: We found the ERBB4 rs839523 CC genotype to be associated with risk for TD occurrence and increased severity as measured by the Abnormal Involuntary Movement Scale (AIMS) (P =.003). Conclusions: This study supports a role for the neuregulin signalling pathway in TD, although independent replications are warranted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 91-95 |
| Number of pages | 5 |
| Journal | World Journal of Biological Psychiatry |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2 2019 |
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Keywords
- Tardive dyskinesia
- neuregulin 1 (NRG1)
- pharmacogenetics
- receptor tyrosine-protein kinase erbB-4 (ERBB4)
- schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
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Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia. / Zai, Clement C.; Tiwari, Arun K.; Chowdhury, Nabilah I.; Yilmaz, Zeynep; de Luca, Vincenzo; Müller, Daniel J.; Potkin, Steven G.; Lieberman, Jeffrey A.; Meltzer, Herbert Y; Voineskos, Aristotle N.; Remington, Gary; Kennedy, James L.
In: World Journal of Biological Psychiatry, Vol. 20, No. 1, 02.01.2019, p. 91-95.Research output: Contribution to journal › Article
TY - JOUR
T1 - Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia
AU - Zai, Clement C.
AU - Tiwari, Arun K.
AU - Chowdhury, Nabilah I.
AU - Yilmaz, Zeynep
AU - de Luca, Vincenzo
AU - Müller, Daniel J.
AU - Potkin, Steven G.
AU - Lieberman, Jeffrey A.
AU - Meltzer, Herbert Y
AU - Voineskos, Aristotle N.
AU - Remington, Gary
AU - Kennedy, James L.
PY - 2019/1/2
Y1 - 2019/1/2
N2 - Objectives: Tardive dyskinesia (TD) is a movement disorder that may develop as a side effect of antipsychotic medication. The aetiology underlying TD is unclear, but a number of mechanisms have been proposed. Methods: We investigated single-nucleotide polymorphisms (SNPs) in the genes coding for neuregulin-1 and erbB-4 receptor in our sample of 153 European schizophrenia patients for possible association with TD. Results: We found the ERBB4 rs839523 CC genotype to be associated with risk for TD occurrence and increased severity as measured by the Abnormal Involuntary Movement Scale (AIMS) (P =.003). Conclusions: This study supports a role for the neuregulin signalling pathway in TD, although independent replications are warranted.
AB - Objectives: Tardive dyskinesia (TD) is a movement disorder that may develop as a side effect of antipsychotic medication. The aetiology underlying TD is unclear, but a number of mechanisms have been proposed. Methods: We investigated single-nucleotide polymorphisms (SNPs) in the genes coding for neuregulin-1 and erbB-4 receptor in our sample of 153 European schizophrenia patients for possible association with TD. Results: We found the ERBB4 rs839523 CC genotype to be associated with risk for TD occurrence and increased severity as measured by the Abnormal Involuntary Movement Scale (AIMS) (P =.003). Conclusions: This study supports a role for the neuregulin signalling pathway in TD, although independent replications are warranted.
KW - Tardive dyskinesia
KW - neuregulin 1 (NRG1)
KW - pharmacogenetics
KW - receptor tyrosine-protein kinase erbB-4 (ERBB4)
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85017224338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017224338&partnerID=8YFLogxK
U2 - 10.1080/15622975.2017.1301681
DO - 10.1080/15622975.2017.1301681
M3 - Article
VL - 20
SP - 91
EP - 95
JO - World Journal of Biological Psychiatry
JF - World Journal of Biological Psychiatry
SN - 1562-2975
IS - 1
ER -