Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia

Clement C. Zai*, Arun K. Tiwari, Nabilah I. Chowdhury, Zeynep Yilmaz, Vincenzo de Luca, Daniel J. Müller, Steven G. Potkin, Jeffrey A. Lieberman, Herbert Y Meltzer, Aristotle N. Voineskos, Gary Remington, James L. Kennedy

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: Tardive dyskinesia (TD) is a movement disorder that may develop as a side effect of antipsychotic medication. The aetiology underlying TD is unclear, but a number of mechanisms have been proposed. Methods: We investigated single-nucleotide polymorphisms (SNPs) in the genes coding for neuregulin-1 and erbB-4 receptor in our sample of 153 European schizophrenia patients for possible association with TD. Results: We found the ERBB4 rs839523 CC genotype to be associated with risk for TD occurrence and increased severity as measured by the Abnormal Involuntary Movement Scale (AIMS) (P =.003). Conclusions: This study supports a role for the neuregulin signalling pathway in TD, although independent replications are warranted.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalWorld Journal of Biological Psychiatry
Volume20
Issue number1
DOIs
StatePublished - Jan 2 2019

Fingerprint

Neuregulin-1
Neuregulins
Movement Disorders
Antipsychotic Agents
Single Nucleotide Polymorphism
Schizophrenia
Genotype
ErbB-4 Receptor
Tardive Dyskinesia
Genes

Keywords

  • Tardive dyskinesia
  • neuregulin 1 (NRG1)
  • pharmacogenetics
  • receptor tyrosine-protein kinase erbB-4 (ERBB4)
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Zai, C. C., Tiwari, A. K., Chowdhury, N. I., Yilmaz, Z., de Luca, V., Müller, D. J., ... Kennedy, J. L. (2019). Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia. World Journal of Biological Psychiatry, 20(1), 91-95. https://doi.org/10.1080/15622975.2017.1301681
Zai, Clement C. ; Tiwari, Arun K. ; Chowdhury, Nabilah I. ; Yilmaz, Zeynep ; de Luca, Vincenzo ; Müller, Daniel J. ; Potkin, Steven G. ; Lieberman, Jeffrey A. ; Meltzer, Herbert Y ; Voineskos, Aristotle N. ; Remington, Gary ; Kennedy, James L. / Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia. In: World Journal of Biological Psychiatry. 2019 ; Vol. 20, No. 1. pp. 91-95.
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Zai, CC, Tiwari, AK, Chowdhury, NI, Yilmaz, Z, de Luca, V, Müller, DJ, Potkin, SG, Lieberman, JA, Meltzer, HY, Voineskos, AN, Remington, G & Kennedy, JL 2019, 'Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia', World Journal of Biological Psychiatry, vol. 20, no. 1, pp. 91-95. https://doi.org/10.1080/15622975.2017.1301681

Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia. / Zai, Clement C.; Tiwari, Arun K.; Chowdhury, Nabilah I.; Yilmaz, Zeynep; de Luca, Vincenzo; Müller, Daniel J.; Potkin, Steven G.; Lieberman, Jeffrey A.; Meltzer, Herbert Y; Voineskos, Aristotle N.; Remington, Gary; Kennedy, James L.

In: World Journal of Biological Psychiatry, Vol. 20, No. 1, 02.01.2019, p. 91-95.

Research output: Contribution to journalArticle

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AU - Zai, Clement C.

AU - Tiwari, Arun K.

AU - Chowdhury, Nabilah I.

AU - Yilmaz, Zeynep

AU - de Luca, Vincenzo

AU - Müller, Daniel J.

AU - Potkin, Steven G.

AU - Lieberman, Jeffrey A.

AU - Meltzer, Herbert Y

AU - Voineskos, Aristotle N.

AU - Remington, Gary

AU - Kennedy, James L.

PY - 2019/1/2

Y1 - 2019/1/2

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