Abstract
Objectives: Tardive dyskinesia (TD) is a movement disorder that may develop as a side effect of antipsychotic medication. The aetiology underlying TD is unclear, but a number of mechanisms have been proposed. Methods: We investigated single-nucleotide polymorphisms (SNPs) in the genes coding for neuregulin-1 and erbB-4 receptor in our sample of 153 European schizophrenia patients for possible association with TD. Results: We found the ERBB4 rs839523 CC genotype to be associated with risk for TD occurrence and increased severity as measured by the Abnormal Involuntary Movement Scale (AIMS) (P =.003). Conclusions: This study supports a role for the neuregulin signalling pathway in TD, although independent replications are warranted.
Original language | English (US) |
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Pages (from-to) | 91-95 |
Number of pages | 5 |
Journal | World Journal of Biological Psychiatry |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2 2019 |
Keywords
- Tardive dyskinesia
- neuregulin 1 (NRG1)
- pharmacogenetics
- receptor tyrosine-protein kinase erbB-4 (ERBB4)
- schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry