TY - JOUR
T1 - Genetic Testing for Parkinson Disease
T2 - Are We Ready?
AU - Cook, Lola
AU - Schulze, Jeanine
AU - Kopil, Catherine
AU - Hastings, Tara
AU - Naito, Anna
AU - Wojcieszek, Joanne
AU - Payne, Katelyn
AU - Alcalay, Roy N.
AU - Klein, Christine
AU - Saunders-Pullman, Rachel
AU - Simuni, Tatyana
AU - Foroud, Tatiana
N1 - Publisher Copyright:
© American Academy of Neurology.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - Purpose of ReviewWith the advent of precision medicine and demand for genomic testing information, we may question whether it is time to offer genetic testing to our patients with Parkinson disease (PD). This review updates the current genetic landscape of PD, describes what genetic testing may offer, provides strategies for evaluating whom to test, and provides resources for the busy clinician.Recent FindingsPatients with PD and their relatives, in various settings, have expressed an interest in learning their PD genetic status; however, physicians may be hesitant to widely offer testing due to the perceived low clinical utility of PD genetic test results. The rise of clinical trials available for patients with gene-specific PD and emerging information on genotype-phenotype correlations are starting to shift this discussion about testing.SummaryBy learning more about the various genetic testing options for PD and utility of results for patients and their care, clinicians may become more comfortable with widespread PD genetic testing in the research and clinical setting.
AB - Purpose of ReviewWith the advent of precision medicine and demand for genomic testing information, we may question whether it is time to offer genetic testing to our patients with Parkinson disease (PD). This review updates the current genetic landscape of PD, describes what genetic testing may offer, provides strategies for evaluating whom to test, and provides resources for the busy clinician.Recent FindingsPatients with PD and their relatives, in various settings, have expressed an interest in learning their PD genetic status; however, physicians may be hesitant to widely offer testing due to the perceived low clinical utility of PD genetic test results. The rise of clinical trials available for patients with gene-specific PD and emerging information on genotype-phenotype correlations are starting to shift this discussion about testing.SummaryBy learning more about the various genetic testing options for PD and utility of results for patients and their care, clinicians may become more comfortable with widespread PD genetic testing in the research and clinical setting.
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U2 - 10.1212/CPJ.0000000000000831
DO - 10.1212/CPJ.0000000000000831
M3 - Review article
C2 - 33968475
AN - SCOPUS:85148212791
SN - 2163-0402
VL - 11
SP - 69
EP - 77
JO - Neurology: Clinical Practice
JF - Neurology: Clinical Practice
IS - 1
ER -