Abstract
Two studies were undertaken to determine a possible genetic basis for alterations in phospholipid metabolism in schizophrenia. Initial results demonstrated an association in 65 schizophrenics compared with a matched normal control population. A follow-up haplotype relative risk study of 44 triads (mother, father, affected offspring), confirmed the results seen in the association study. Results suggest that a genetic variant near the promotor region of the gene for cytosolic phospholipase A2, the rate-limiting enzyme in the synthesis of prostaglandins from arachidonic acid, is associated with schizophrenia.
Original language | English (US) |
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Pages (from-to) | 111-116 |
Number of pages | 6 |
Journal | Schizophrenia Research |
Volume | 21 |
Issue number | 2 |
DOIs | |
State | Published - Aug 23 1996 |
Keywords
- Genetic association
- Genetic polymorphism
- Haplotype relative risk
- Phospholipase A
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry