Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population

Naoko Iwasaki; Yukio Horikawa; Takafumi Tsuchiya; Yutaka Kitamura; Takahiro Nakamura; Yukio Tanizawa; Yoshitomo Oka; Kazuo Hara; Takashi Kadowaki; Takuya Awata; Masashi Honda; Katsuko Yamashita; Naohisa Oda; Li Yu; Norihiro Yamada; Makiko Ogata; Naoyuki Kamatani; Yasuhiko Iwamoto; Laura Del Bosque-Plata; M. Geoffrey Hayes; Nancy J. Cox; Graeme I. Bell

doi:10.1007/s10038-004-0225-5

Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population

Naoko Iwasaki^*, Yukio Horikawa, Takafumi Tsuchiya, Yutaka Kitamura, Takahiro Nakamura, Yukio Tanizawa, Yoshitomo Oka, Kazuo Hara, Takashi Kadowaki, Takuya Awata, Masashi Honda, Katsuko Yamashita, Naohisa Oda, Li Yu, Norihiro Yamada, Makiko Ogata, Naoyuki Kamatani, Yasuhiko Iwamoto, Laura Del Bosque-Plata, M. Geoffrey HayesNancy J. Cox, Graeme I. Bell

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Variation in the gene encoding the cysteine protease calpain-10 has been linked and associated with risk of type 2 diabetes. We have examined the effect of three polymorphisms in the calpain-10 gene (SNP-43, Indel-19, and SNP-63) on the development of type 2 diabetes in the Japanese population in a pooled analysis of 927 patients and 929 controls. We observed that SNP-43, Indel-19, and SNP-63 either individually or as a haplotype were not associated with altered risk of type 2 diabetes with the exception of the rare 111/221 haplogenotype (odds ratio (OR) =3.53, P=0.02). However, stratification based on the median age-at-diagnosis in the pooled study population (<50 and ≥50 years) revealed that allele 2 of Indel-19 and the 121 haplotype were associated with reduced risk in patients with later age-at-diagnosis (age-at-diagnosis ≥50 years OR=0.82 and 0.80, respectively; P=0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals.

Original language	English (US)
Pages (from-to)	92-98
Number of pages	7
Journal	Journal of Human Genetics
Volume	50
Issue number	2
DOIs	https://doi.org/10.1007/s10038-004-0225-5
State	Published - Feb 2005

Keywords

Age-at-diagnosis
Association study
Calpain-10
Genetics
Polymorphism
Type 2 diabetes

ASJC Scopus subject areas

Genetics(clinical)
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10038-004-0225-5

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Iwasaki, N., Horikawa, Y., Tsuchiya, T., Kitamura, Y., Nakamura, T., Tanizawa, Y., Oka, Y., Hara, K., Kadowaki, T., Awata, T., Honda, M., Yamashita, K., Oda, N., Yu, L., Yamada, N., Ogata, M., Kamatani, N., Iwamoto, Y., Del Bosque-Plata, L., ... Bell, G. I. (2005). Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population. Journal of Human Genetics, 50(2), 92-98. https://doi.org/10.1007/s10038-004-0225-5

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title = "Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population",

abstract = "Variation in the gene encoding the cysteine protease calpain-10 has been linked and associated with risk of type 2 diabetes. We have examined the effect of three polymorphisms in the calpain-10 gene (SNP-43, Indel-19, and SNP-63) on the development of type 2 diabetes in the Japanese population in a pooled analysis of 927 patients and 929 controls. We observed that SNP-43, Indel-19, and SNP-63 either individually or as a haplotype were not associated with altered risk of type 2 diabetes with the exception of the rare 111/221 haplogenotype (odds ratio (OR) =3.53, P=0.02). However, stratification based on the median age-at-diagnosis in the pooled study population (<50 and ≥50 years) revealed that allele 2 of Indel-19 and the 121 haplotype were associated with reduced risk in patients with later age-at-diagnosis (age-at-diagnosis ≥50 years OR=0.82 and 0.80, respectively; P=0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals.",

keywords = "Age-at-diagnosis, Association study, Calpain-10, Genetics, Polymorphism, Type 2 diabetes",

author = "Naoko Iwasaki and Yukio Horikawa and Takafumi Tsuchiya and Yutaka Kitamura and Takahiro Nakamura and Yukio Tanizawa and Yoshitomo Oka and Kazuo Hara and Takashi Kadowaki and Takuya Awata and Masashi Honda and Katsuko Yamashita and Naohisa Oda and Li Yu and Norihiro Yamada and Makiko Ogata and Naoyuki Kamatani and Yasuhiko Iwamoto and {Del Bosque-Plata}, Laura and Hayes, {M. Geoffrey} and Cox, {Nancy J.} and Bell, {Graeme I.}",

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Iwasaki, N, Horikawa, Y, Tsuchiya, T, Kitamura, Y, Nakamura, T, Tanizawa, Y, Oka, Y, Hara, K, Kadowaki, T, Awata, T, Honda, M, Yamashita, K, Oda, N, Yu, L, Yamada, N, Ogata, M, Kamatani, N, Iwamoto, Y, Del Bosque-Plata, L, Hayes, MG, Cox, NJ & Bell, GI 2005, 'Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population', Journal of Human Genetics, vol. 50, no. 2, pp. 92-98. https://doi.org/10.1007/s10038-004-0225-5

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T1 - Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population

AU - Iwasaki, Naoko

AU - Horikawa, Yukio

AU - Tsuchiya, Takafumi

AU - Kitamura, Yutaka

AU - Nakamura, Takahiro

AU - Tanizawa, Yukio

AU - Oka, Yoshitomo

AU - Hara, Kazuo

AU - Kadowaki, Takashi

AU - Awata, Takuya

AU - Honda, Masashi

AU - Yamashita, Katsuko

AU - Oda, Naohisa

AU - Yu, Li

AU - Yamada, Norihiro

AU - Ogata, Makiko

AU - Kamatani, Naoyuki

AU - Iwamoto, Yasuhiko

AU - Del Bosque-Plata, Laura

AU - Hayes, M. Geoffrey

AU - Cox, Nancy J.

AU - Bell, Graeme I.

PY - 2005/2

Y1 - 2005/2

N2 - Variation in the gene encoding the cysteine protease calpain-10 has been linked and associated with risk of type 2 diabetes. We have examined the effect of three polymorphisms in the calpain-10 gene (SNP-43, Indel-19, and SNP-63) on the development of type 2 diabetes in the Japanese population in a pooled analysis of 927 patients and 929 controls. We observed that SNP-43, Indel-19, and SNP-63 either individually or as a haplotype were not associated with altered risk of type 2 diabetes with the exception of the rare 111/221 haplogenotype (odds ratio (OR) =3.53, P=0.02). However, stratification based on the median age-at-diagnosis in the pooled study population (<50 and ≥50 years) revealed that allele 2 of Indel-19 and the 121 haplotype were associated with reduced risk in patients with later age-at-diagnosis (age-at-diagnosis ≥50 years OR=0.82 and 0.80, respectively; P=0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals.

AB - Variation in the gene encoding the cysteine protease calpain-10 has been linked and associated with risk of type 2 diabetes. We have examined the effect of three polymorphisms in the calpain-10 gene (SNP-43, Indel-19, and SNP-63) on the development of type 2 diabetes in the Japanese population in a pooled analysis of 927 patients and 929 controls. We observed that SNP-43, Indel-19, and SNP-63 either individually or as a haplotype were not associated with altered risk of type 2 diabetes with the exception of the rare 111/221 haplogenotype (odds ratio (OR) =3.53, P=0.02). However, stratification based on the median age-at-diagnosis in the pooled study population (<50 and ≥50 years) revealed that allele 2 of Indel-19 and the 121 haplotype were associated with reduced risk in patients with later age-at-diagnosis (age-at-diagnosis ≥50 years OR=0.82 and 0.80, respectively; P=0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals.

KW - Age-at-diagnosis

KW - Association study

KW - Calpain-10

KW - Genetics

KW - Polymorphism

KW - Type 2 diabetes

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AN - SCOPUS:20144388438

SN - 1434-5161

VL - 50

SP - 92

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JO - Journal of Human Genetics

JF - Journal of Human Genetics

IS - 2

ER -

Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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