Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population

Naoko Iwasaki*, Yukio Horikawa, Takafumi Tsuchiya, Yutaka Kitamura, Takahiro Nakamura, Yukio Tanizawa, Yoshitomo Oka, Kazuo Hara, Takashi Kadowaki, Takuya Awata, Masashi Honda, Katsuko Yamashita, Naohisa Oda, Li Yu, Norihiro Yamada, Makiko Ogata, Naoyuki Kamatani, Yasuhiko Iwamoto, Laura Del Bosque-Plata, M. Geoffrey HayesNancy J. Cox, Graeme I. Bell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Variation in the gene encoding the cysteine protease calpain-10 has been linked and associated with risk of type 2 diabetes. We have examined the effect of three polymorphisms in the calpain-10 gene (SNP-43, Indel-19, and SNP-63) on the development of type 2 diabetes in the Japanese population in a pooled analysis of 927 patients and 929 controls. We observed that SNP-43, Indel-19, and SNP-63 either individually or as a haplotype were not associated with altered risk of type 2 diabetes with the exception of the rare 111/221 haplogenotype (odds ratio (OR) =3.53, P=0.02). However, stratification based on the median age-at-diagnosis in the pooled study population (<50 and ≥50 years) revealed that allele 2 of Indel-19 and the 121 haplotype were associated with reduced risk in patients with later age-at-diagnosis (age-at-diagnosis ≥50 years OR=0.82 and 0.80, respectively; P=0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals.

Original languageEnglish (US)
Pages (from-to)92-98
Number of pages7
JournalJournal of Human Genetics
Volume50
Issue number2
DOIs
StatePublished - Feb 2005

Keywords

  • Age-at-diagnosis
  • Association study
  • Calpain-10
  • Genetics
  • Polymorphism
  • Type 2 diabetes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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