Genetic variation in a4GnT in relation to helicobacter pylori serology and gastric cancer risk

Zongli Zheng, Yanbin Jia, Lifang Hou, Christina Persson, Meredith Yeager, Jolanta Lissowska, Stephen J. Chanock, Martin Blaser, Wong Ho Chow, Weimin Ye*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Helicobacter pylori, a known risk factor of gastric cancer, rarely colonize the deeper portion of normal gastric glands, where the mucus is rich in α-1,4-linked N-acetylglucosamine capped O-glycans, that strongly inhibit H. pylori growth in vitro. Materials and methods: We investigated the association between genetic variation in the O-glycan transferase encoding gene (a4GnT) and H. pylori infection and gastric cancer risk using a Polish population-based case-control study (273 gastric cancer patients and 377 controls). Results: A haplotype at the rs2622694-rs397266 locus was associated with H. pylori infection, with the A-A haplotype associated with a higher risk compared with the most frequent G-G haplotype (odds ratio 2.30; 95% confidence interval 1.35-3.92). The association remained significant after correction for multiple tests (global p value: nominal 0.002, empirical 0.045). Neither this haplotype nor the tagSNPs were associated with overall gastric cancer risk. Conclusion: a4GnT genetic variation may be relevant to H. pylori infection, but not to gastric cancer risk.

Original languageEnglish (US)
Pages (from-to)472-477
Number of pages6
JournalHelicobacter
Volume14
Issue number5
DOIs
StatePublished - Oct 2009

Keywords

  • Gastric cancer
  • Genetic susceptibility
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases

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