Genetically determined resistance mechanisms in leukemia

R. S. Schwartz, S. K. Datta

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

It now seems unlikely that the theory of immunologic surveillance can satisfactorily explain how neoplasms arise from a nidus of transformed cells. The development of neoplasms is a multistage process, with one or more genetic controls at each step. Immunologic factors constitute only one, perhaps minor element, in the pathway. In the case of viral oncogenesis, immunologic surveillance exists, but as a special case of antiviral immunity. Susceptibility or resistance to leukemia viruses in mice may hinge on the action of a single gene. Such a gene may exert controls that are completely unrelated to the immune system. Thus leukemia can develop in an immunologically 'normal' individual who possesses atypical viral genetic information.

Original languageEnglish (US)
Pages (from-to)591-604
Number of pages14
JournalBlood Cells
Volume3
Issue number3
Publication statusPublished - Jan 1 1977

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ASJC Scopus subject areas

  • Hematology

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