Genetics, epigenetics, and regulation of drug-metabolizing cytochrome P450 enzymes

U. M. Zanger*, K. Klein, M. Thomas, J. K. Rieger, R. Tremmel, B. A. Kandel, M. Klein, T. Magdy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Of 57 functional human cytochrome P450 (CYP) isoforms, about a dozen liver-expressed, highly variable forms are responsible for the biotransformation of most drugs. Owing to numerous genetic and nongenetic sources of variation, each individual possesses his/her own, rather unique, CYP profile. Here, we explore the potential of new technologies and developments in genetics, epigenetics, and the regulation of gene expression to increase our understanding of the mechanisms that lead to the enormous inter- and intraindividual variability of these enzymes.

Original languageEnglish (US)
Pages (from-to)258-261
Number of pages4
JournalClinical pharmacology and therapeutics
Volume95
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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