Genetics of Amyotrophic Lateral Sclerosis

Nailah Siddique, Teepu Siddique*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Amyotrophic lateral sclerosis (ALS) was first described by Charcot in 1869 as what we would now call a sporadic disease-a disease believed to occur without a strong genetic influence. Only within the past 10 years has it been possible to fully explore genetic influence on disorders that seem to occur sporadically but likely result from the convergence of multiple genetic and environmental factors. This article reviews the genetics of familial ALS and summarizes current investigations of genetic influence in sporadic ALS. Genetic study clearly offers the potential for identification of molecular targets that would allow development of rational therapies for various forms of ALS, but much work remains.

Original languageEnglish (US)
Pages (from-to)429-439
Number of pages11
JournalPhysical Medicine and Rehabilitation Clinics of North America
Issue number3
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

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