Genetics of Cardiac Developmental Disorders: Cardiomyocyte Proliferation and Growth and Relevance to Heart Failure

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Cardiac developmental disorders represent the most common of human birth defects, and anomalies in cardiomyocyte proliferation drive many of these disorders. This review highlights the molecular mechanisms of prenatal cardiac growth. Trabeculation represents the initial ventricular growth phase and is necessary for embryonic survival. Later in development, the bulk of the ventricular wall derives from the compaction process, yet the arrest of this process can still be compatible with life. Cardiomyocyte proliferation and growth form the basis of both trabeculation and compaction, and mouse models indicate that cardiomyocyte interactions with the surrounding environment are critical for these proliferative processes. The human genetics of left ventricular noncompaction cardiomyopathy suggest that cardiomyocyte cell-autonomous mechanisms contribute to the compaction process. Understanding the determinants of prenatal or early postnatal cardiomyocyte proliferation and growth provides critical information that identifies risk factors for cardiovascular disease, including heart failure and its associated complications of arrhythmias and thromboembolic events.

Original languageEnglish (US)
Pages (from-to)395-419
Number of pages25
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume11
DOIs
StatePublished - May 23 2016

Fingerprint

heart failure
Cardiac Myocytes
Heart Failure
Growth
cardiomyopathy
arrhythmia
Medical Genetics
Cardiomyopathies
cardiovascular diseases
Cardiac Arrhythmias
Cardiovascular Diseases
risk factors
animal models
cardiomyocytes
Survival
cells

Keywords

  • Cardiomyopathy
  • Left ventricular noncompaction
  • Myocardial development
  • Noncompaction
  • Trabeculation

ASJC Scopus subject areas

  • Medicine(all)
  • Plant Science

Cite this

@article{6f222969ace6482f9feaffd79e8f7570,
title = "Genetics of Cardiac Developmental Disorders: Cardiomyocyte Proliferation and Growth and Relevance to Heart Failure",
abstract = "Cardiac developmental disorders represent the most common of human birth defects, and anomalies in cardiomyocyte proliferation drive many of these disorders. This review highlights the molecular mechanisms of prenatal cardiac growth. Trabeculation represents the initial ventricular growth phase and is necessary for embryonic survival. Later in development, the bulk of the ventricular wall derives from the compaction process, yet the arrest of this process can still be compatible with life. Cardiomyocyte proliferation and growth form the basis of both trabeculation and compaction, and mouse models indicate that cardiomyocyte interactions with the surrounding environment are critical for these proliferative processes. The human genetics of left ventricular noncompaction cardiomyopathy suggest that cardiomyocyte cell-autonomous mechanisms contribute to the compaction process. Understanding the determinants of prenatal or early postnatal cardiomyocyte proliferation and growth provides critical information that identifies risk factors for cardiovascular disease, including heart failure and its associated complications of arrhythmias and thromboembolic events.",
keywords = "Cardiomyopathy, Left ventricular noncompaction, Myocardial development, Noncompaction, Trabeculation",
author = "Wilsbacher, {Lisa D} and McNally, {Elizabeth M}",
year = "2016",
month = "5",
day = "23",
doi = "10.1146/annurev-pathol-012615-044336",
language = "English (US)",
volume = "11",
pages = "395--419",
journal = "Annual Review of Pathology: Mechanisms of Disease",
issn = "1553-4006",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Genetics of Cardiac Developmental Disorders

T2 - Cardiomyocyte Proliferation and Growth and Relevance to Heart Failure

AU - Wilsbacher, Lisa D

AU - McNally, Elizabeth M

PY - 2016/5/23

Y1 - 2016/5/23

N2 - Cardiac developmental disorders represent the most common of human birth defects, and anomalies in cardiomyocyte proliferation drive many of these disorders. This review highlights the molecular mechanisms of prenatal cardiac growth. Trabeculation represents the initial ventricular growth phase and is necessary for embryonic survival. Later in development, the bulk of the ventricular wall derives from the compaction process, yet the arrest of this process can still be compatible with life. Cardiomyocyte proliferation and growth form the basis of both trabeculation and compaction, and mouse models indicate that cardiomyocyte interactions with the surrounding environment are critical for these proliferative processes. The human genetics of left ventricular noncompaction cardiomyopathy suggest that cardiomyocyte cell-autonomous mechanisms contribute to the compaction process. Understanding the determinants of prenatal or early postnatal cardiomyocyte proliferation and growth provides critical information that identifies risk factors for cardiovascular disease, including heart failure and its associated complications of arrhythmias and thromboembolic events.

AB - Cardiac developmental disorders represent the most common of human birth defects, and anomalies in cardiomyocyte proliferation drive many of these disorders. This review highlights the molecular mechanisms of prenatal cardiac growth. Trabeculation represents the initial ventricular growth phase and is necessary for embryonic survival. Later in development, the bulk of the ventricular wall derives from the compaction process, yet the arrest of this process can still be compatible with life. Cardiomyocyte proliferation and growth form the basis of both trabeculation and compaction, and mouse models indicate that cardiomyocyte interactions with the surrounding environment are critical for these proliferative processes. The human genetics of left ventricular noncompaction cardiomyopathy suggest that cardiomyocyte cell-autonomous mechanisms contribute to the compaction process. Understanding the determinants of prenatal or early postnatal cardiomyocyte proliferation and growth provides critical information that identifies risk factors for cardiovascular disease, including heart failure and its associated complications of arrhythmias and thromboembolic events.

KW - Cardiomyopathy

KW - Left ventricular noncompaction

KW - Myocardial development

KW - Noncompaction

KW - Trabeculation

UR - http://www.scopus.com/inward/record.url?scp=84971280150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971280150&partnerID=8YFLogxK

U2 - 10.1146/annurev-pathol-012615-044336

DO - 10.1146/annurev-pathol-012615-044336

M3 - Article

C2 - 26925501

AN - SCOPUS:84971280150

VL - 11

SP - 395

EP - 419

JO - Annual Review of Pathology: Mechanisms of Disease

JF - Annual Review of Pathology: Mechanisms of Disease

SN - 1553-4006

ER -