Genetics of chronic rhinosinusitis: State of the field and directions forward

Joy Hsu, Pedro C. Avila, Robert C. Kern, M. Geoffrey Hayes, Robert P. Schleimer, Jayant M. Pinto*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

The cause of chronic rhinosinusitis (CRS) remains unclear. Study of the genetic susceptibility to CRS might be a valuable strategy to understand the pathogenesis of this burdensome disorder. The purpose of this review is to critically evaluate the current literature regarding the genetics of CRS in a comprehensive fashion. The most promising findings from candidate gene studies include the cystic fibrosis transmembrane conductance regulator gene (CFTR), as well as genes involved in antigen presentation, innate and adaptive immune responses, tissue remodeling, and arachidonic acid metabolism. We also review the few hypothesis-independent genetic studies of CRS (ie, linkage analysis and pooling-based genome-wide association studies). Interpretation of the current literature is limited by challenges with study design, sparse replication, few functional correlates of associated polymorphisms, and inadequate examination of linkage disequilibrium or expression quantitative trait loci for reported associations. Given the relationship of CRS to other airway disorders with well-characterized genetic components (eg, asthma), study of the genetics of CRS deserves increased attention and investment, including the organization of large, detailed, and collaborative studies to advance knowledge of the mechanisms that underlie this disorder.

Original languageEnglish (US)
Pages (from-to)977-993.e5
JournalJournal of Allergy and Clinical Immunology
Volume131
Issue number4
DOIs
StatePublished - Apr 2013

Keywords

  • Genetics
  • candidate gene
  • chronic rhinosinusitis
  • genome
  • genome wide association study
  • linkage
  • nasal polyposis
  • polymorphism
  • single nucleotide polymorphism
  • sinusitis
  • susceptibility
  • variation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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