Genetics of Common Neurological Disorders

Jinger G. Hoop*, Edwin H. Cook, Stephen H. Dinwiddie, Elliot S. Gershon

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


The understanding of the complex, multifactorial genetic mechanisms underlying common adult neurological disorders such as Alzheimer's disease, Parkinson's disease, autism, epilepsies, schizophrenia and bipolar disease is rapidly unfolding. While the clinical effects of a few specific mutations are relatively clear, it is premature to regard genetic testing for most applications as an accepted component of clinical management with defined test accuracies and clinical validities. Caution, careful correlation of heritability with clinical outcomes, and further research are needed before susceptibility and diagnostic genetic testing will become routine care.

Original languageEnglish (US)
Title of host publicationGenetic Testing
Subtitle of host publicationCare, Consent, and Liability
PublisherJohn Wiley & Sons, Inc.
Number of pages19
ISBN (Print)0471649872, 9780471649878
StatePublished - Jan 4 2006


  • Alzheimer
  • Autism
  • Behavior
  • Bipolar
  • Epilepsy
  • Heritability
  • Multifactorial
  • Neurodegenerative
  • Neurogenetic
  • Parkinson
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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