Genetics of Mitochondrial Electron Transport Chain in Regulating Oxygen Sensing

Eric L. Bell; Navdeep S. Chandel

doi:10.1016/S0076-6879(07)35023-4

Genetics of Mitochondrial Electron Transport Chain in Regulating Oxygen Sensing

Eric L. Bell^*, Navdeep S. Chandel

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Chapter in Book/Report/Conference proceeding › Chapter

14 Scopus citations

Abstract

Oxygen is the terminal electron acceptor in the mitochondrial electron transport chain and therefore is required for the generation of energy through oxidative phosphorylation. In environments of decreased oxygen levels (hypoxia), organisms have developed an adaptive response through the activation of the hypoxia-inducible transcription factor (HIF) to maintain their energetic demand. In order to sense hypoxic environments, cells have developed oxygen-sensing machinery that allows for the activation of HIF. The mitochondrial electron transport chain is required for the oxygen-sensing pathway. This chapter outlines methods used to explore the role of the electron transport chain and a by-product of electron transport, reactive oxygen species, in oxygen sensing.

Original language	English (US)
Title of host publication	Oxygen Biology and Hypoxia
Editors	Helmut Sies, Bernhard Brune
Pages	447-461
Number of pages	15
DOIs	https://doi.org/10.1016/S0076-6879(07)35023-4
State	Published - 2007

Publication series

Name	Methods in Enzymology
Volume	435
ISSN (Print)	0076-6879

Funding

This work was supported in part by National Institutes of Health Grants (GM60472‐07) to Navdeep S. Chandel. Eric Bell is supported by the American Heart Association Grant (0515563Z).

ASJC Scopus subject areas

Molecular Biology
Biochemistry

Access to Document

10.1016/S0076-6879(07)35023-4

Cite this

@inbook{f31f178a4eb54a119713193c68706d44,

title = "Genetics of Mitochondrial Electron Transport Chain in Regulating Oxygen Sensing",

abstract = "Oxygen is the terminal electron acceptor in the mitochondrial electron transport chain and therefore is required for the generation of energy through oxidative phosphorylation. In environments of decreased oxygen levels (hypoxia), organisms have developed an adaptive response through the activation of the hypoxia-inducible transcription factor (HIF) to maintain their energetic demand. In order to sense hypoxic environments, cells have developed oxygen-sensing machinery that allows for the activation of HIF. The mitochondrial electron transport chain is required for the oxygen-sensing pathway. This chapter outlines methods used to explore the role of the electron transport chain and a by-product of electron transport, reactive oxygen species, in oxygen sensing.",

author = "Bell, {Eric L.} and Chandel, {Navdeep S.}",

note = "Funding Information: This work was supported in part by National Institutes of Health Grants (GM60472‐07) to Navdeep S. Chandel. Eric Bell is supported by the American Heart Association Grant (0515563Z).",

year = "2007",

doi = "10.1016/S0076-6879(07)35023-4",

language = "English (US)",

isbn = "9780123739704",

series = "Methods in Enzymology",

pages = "447--461",

editor = "Helmut Sies and Bernhard Brune",

booktitle = "Oxygen Biology and Hypoxia",

}

TY - CHAP

T1 - Genetics of Mitochondrial Electron Transport Chain in Regulating Oxygen Sensing

AU - Bell, Eric L.

AU - Chandel, Navdeep S.

N1 - Funding Information: This work was supported in part by National Institutes of Health Grants (GM60472‐07) to Navdeep S. Chandel. Eric Bell is supported by the American Heart Association Grant (0515563Z).

PY - 2007

Y1 - 2007

N2 - Oxygen is the terminal electron acceptor in the mitochondrial electron transport chain and therefore is required for the generation of energy through oxidative phosphorylation. In environments of decreased oxygen levels (hypoxia), organisms have developed an adaptive response through the activation of the hypoxia-inducible transcription factor (HIF) to maintain their energetic demand. In order to sense hypoxic environments, cells have developed oxygen-sensing machinery that allows for the activation of HIF. The mitochondrial electron transport chain is required for the oxygen-sensing pathway. This chapter outlines methods used to explore the role of the electron transport chain and a by-product of electron transport, reactive oxygen species, in oxygen sensing.

AB - Oxygen is the terminal electron acceptor in the mitochondrial electron transport chain and therefore is required for the generation of energy through oxidative phosphorylation. In environments of decreased oxygen levels (hypoxia), organisms have developed an adaptive response through the activation of the hypoxia-inducible transcription factor (HIF) to maintain their energetic demand. In order to sense hypoxic environments, cells have developed oxygen-sensing machinery that allows for the activation of HIF. The mitochondrial electron transport chain is required for the oxygen-sensing pathway. This chapter outlines methods used to explore the role of the electron transport chain and a by-product of electron transport, reactive oxygen species, in oxygen sensing.

UR - http://www.scopus.com/inward/record.url?scp=39749171784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39749171784&partnerID=8YFLogxK

U2 - 10.1016/S0076-6879(07)35023-4

DO - 10.1016/S0076-6879(07)35023-4

M3 - Chapter

C2 - 17998068

AN - SCOPUS:39749171784

SN - 9780123739704

T3 - Methods in Enzymology

SP - 447

EP - 461

BT - Oxygen Biology and Hypoxia

A2 - Sies, Helmut

A2 - Brune, Bernhard

ER -

Genetics of Mitochondrial Electron Transport Chain in Regulating Oxygen Sensing

Abstract

Publication series

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this