Genetics of obsessive-compulsive disorders

New findings and challenges

Marco A. Grados*, John Walkup, Samuel Walford

*Corresponding author for this work

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

A review of the current state of research in the genetics of obsessive-compulsive disorder (OCD) is presented. OCD is a neuropsychiatric condition that affects 1-2% of the population and often has an early age at onset of symptoms. OCD has been shown to be familial, and a major gene effect has been reported. However, phenotypic and genetic heterogeneity of OCD poses multiple challenges for locating susceptibility genes. Strategies such as the use of phenotypic subtyping (using tic disorders or other anxiety disorders) and endophenotyping based on brain mechanisms underlying OCD (functional brain imaging and neuropsychological measures) may open ways to understand the genetic components of OCD. Using child probands and extended families for linkage an association studies is another venue to obtain greater informative families for genetic studies. A better understanding of environmental triggers, OCD subtypes and OCD pathophysiology will lead to locating genes that confer risk to OCD.

Original languageEnglish (US)
JournalBrain and Development
Volume25
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 2003

Fingerprint

Obsessive-Compulsive Disorder
Tic Disorders
Genes
Genetic Research
Functional Neuroimaging
Genetic Heterogeneity
Anxiety Disorders
Age of Onset
Brain

Keywords

  • Association
  • Genetics
  • Linkage
  • Obsessive-compulsive disorder

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Grados, Marco A. ; Walkup, John ; Walford, Samuel. / Genetics of obsessive-compulsive disorders : New findings and challenges. In: Brain and Development. 2003 ; Vol. 25, No. SUPPL. 1.
@article{7b2a57d02fa249108546e5f20b3f130e,
title = "Genetics of obsessive-compulsive disorders: New findings and challenges",
abstract = "A review of the current state of research in the genetics of obsessive-compulsive disorder (OCD) is presented. OCD is a neuropsychiatric condition that affects 1-2{\%} of the population and often has an early age at onset of symptoms. OCD has been shown to be familial, and a major gene effect has been reported. However, phenotypic and genetic heterogeneity of OCD poses multiple challenges for locating susceptibility genes. Strategies such as the use of phenotypic subtyping (using tic disorders or other anxiety disorders) and endophenotyping based on brain mechanisms underlying OCD (functional brain imaging and neuropsychological measures) may open ways to understand the genetic components of OCD. Using child probands and extended families for linkage an association studies is another venue to obtain greater informative families for genetic studies. A better understanding of environmental triggers, OCD subtypes and OCD pathophysiology will lead to locating genes that confer risk to OCD.",
keywords = "Association, Genetics, Linkage, Obsessive-compulsive disorder",
author = "Grados, {Marco A.} and John Walkup and Samuel Walford",
year = "2003",
month = "1",
day = "1",
doi = "10.1016/S0387-7604(03)90010-6",
language = "English (US)",
volume = "25",
journal = "Brain and Development",
issn = "0387-7604",
publisher = "Elsevier",
number = "SUPPL. 1",

}

Genetics of obsessive-compulsive disorders : New findings and challenges. / Grados, Marco A.; Walkup, John; Walford, Samuel.

In: Brain and Development, Vol. 25, No. SUPPL. 1, 01.01.2003.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetics of obsessive-compulsive disorders

T2 - New findings and challenges

AU - Grados, Marco A.

AU - Walkup, John

AU - Walford, Samuel

PY - 2003/1/1

Y1 - 2003/1/1

N2 - A review of the current state of research in the genetics of obsessive-compulsive disorder (OCD) is presented. OCD is a neuropsychiatric condition that affects 1-2% of the population and often has an early age at onset of symptoms. OCD has been shown to be familial, and a major gene effect has been reported. However, phenotypic and genetic heterogeneity of OCD poses multiple challenges for locating susceptibility genes. Strategies such as the use of phenotypic subtyping (using tic disorders or other anxiety disorders) and endophenotyping based on brain mechanisms underlying OCD (functional brain imaging and neuropsychological measures) may open ways to understand the genetic components of OCD. Using child probands and extended families for linkage an association studies is another venue to obtain greater informative families for genetic studies. A better understanding of environmental triggers, OCD subtypes and OCD pathophysiology will lead to locating genes that confer risk to OCD.

AB - A review of the current state of research in the genetics of obsessive-compulsive disorder (OCD) is presented. OCD is a neuropsychiatric condition that affects 1-2% of the population and often has an early age at onset of symptoms. OCD has been shown to be familial, and a major gene effect has been reported. However, phenotypic and genetic heterogeneity of OCD poses multiple challenges for locating susceptibility genes. Strategies such as the use of phenotypic subtyping (using tic disorders or other anxiety disorders) and endophenotyping based on brain mechanisms underlying OCD (functional brain imaging and neuropsychological measures) may open ways to understand the genetic components of OCD. Using child probands and extended families for linkage an association studies is another venue to obtain greater informative families for genetic studies. A better understanding of environmental triggers, OCD subtypes and OCD pathophysiology will lead to locating genes that confer risk to OCD.

KW - Association

KW - Genetics

KW - Linkage

KW - Obsessive-compulsive disorder

UR - http://www.scopus.com/inward/record.url?scp=2442572701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442572701&partnerID=8YFLogxK

U2 - 10.1016/S0387-7604(03)90010-6

DO - 10.1016/S0387-7604(03)90010-6

M3 - Article

VL - 25

JO - Brain and Development

JF - Brain and Development

SN - 0387-7604

IS - SUPPL. 1

ER -