TY - JOUR
T1 - Genetics of post-traumatic stress disorder
T2 - Review and recommendations for genome-wide association studies
AU - Cornelis, Marilyn C.
AU - Nugent, Nicole R.
AU - Amstadter, Ananda B.
AU - Koenen, Karestan C.
N1 - Funding Information:
Acknowledgments Dr. Cornelis is a recipient of a Canadian Institutes of Health Research Fellowship.
Funding Information:
Dr. Nugent is supported by National Institute of Mental Health grant K01 MH087240.
Funding Information:
Dr. Amstadter is supported by National Institutes of Health grants K12HD055885 and KL2RR029880.
PY - 2010/8
Y1 - 2010/8
N2 - Post-traumatic stress disorder (PTSD) is a prevalent, disabling anxiety disorder that constitutes a major health care burden. Despite evidence supporting a genetic predisposition to PTSD, the precise genetic loci remain unclear. Herein we review the current state and limitations of genetic research on PTSD. Although recent years have seen an exponential increase in the number of studies examining the influence of candidate genes on PTSD diagnosis and symptomatology, most studies have been characterized by relatively low rates of PTSD, with apparent inconsistencies in gene associations linked to marked differences in methodology. We further discuss how current advances in the genetics field can be applied to studies of PTSD, emphasizing the need to adapt a genome-wide approach that facilitates discovery rather than hypothesis testing. Genomewide association studies offer the best opportunity to identify novel "true" risk variants for the disorder that in turn has the potential to inform our understanding of PTSD etiology.
AB - Post-traumatic stress disorder (PTSD) is a prevalent, disabling anxiety disorder that constitutes a major health care burden. Despite evidence supporting a genetic predisposition to PTSD, the precise genetic loci remain unclear. Herein we review the current state and limitations of genetic research on PTSD. Although recent years have seen an exponential increase in the number of studies examining the influence of candidate genes on PTSD diagnosis and symptomatology, most studies have been characterized by relatively low rates of PTSD, with apparent inconsistencies in gene associations linked to marked differences in methodology. We further discuss how current advances in the genetics field can be applied to studies of PTSD, emphasizing the need to adapt a genome-wide approach that facilitates discovery rather than hypothesis testing. Genomewide association studies offer the best opportunity to identify novel "true" risk variants for the disorder that in turn has the potential to inform our understanding of PTSD etiology.
KW - Gene-environment interaction
KW - Genetics
KW - Genome-wide association
KW - Post-traumatic stress disorder
KW - Trauma
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U2 - 10.1007/s11920-010-0126-6
DO - 10.1007/s11920-010-0126-6
M3 - Review article
C2 - 20549395
AN - SCOPUS:77956392717
VL - 12
SP - 313
EP - 326
JO - Current Psychiatry Reports
JF - Current Psychiatry Reports
SN - 1523-3812
IS - 4
ER -
