Genetics of prostate cancer.

Kai Qi Zhang*, Sherry A. Salzman, D. J. Reding, Brian K. Suarez, William J. Catalona, James K. Burmester

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Prostate cancer is the most frequently diagnosed visceral cancer of men, responsible for approximately 40,000 deaths in adult males per year. To identify the genetic causes of prostate cancer, we performed a whole genome scan of affected sib pairs, using DNA markers spaced evenly across the human genome. We demonstrated that regions on chromosomes 1, 4, 5, 7, 8, 11, 16 and 19 might harbor genes that predispose individuals to prostate cancer and may affect tumor growth rate and tumor aggressiveness. Here we present DNA sequence analysis of KIAA 0872 and 17-beta hydroxysteroid dehydrogenase that are located on chromosome 16 within the mapped region, and we demonstrate that neither of these genes carries mutations in the protein coding region or their splice junction sites. These results suggest that these genes are less likely to be associated with the cause of familial prostate cancer.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalClinical medicine & research
Volume1
Issue number1
DOIs
StatePublished - Jan 2003

ASJC Scopus subject areas

  • Community and Home Care

Fingerprint

Dive into the research topics of 'Genetics of prostate cancer.'. Together they form a unique fingerprint.

Cite this