Gene/Viral Treatment Approaches for Malignant Brain Cancer

Julius W. Kim*, Katarzyna C. Pituch, Annie Xiao, Jacob S. Young, Wojciech K. Panek, Megan E. Muroski, Aida Rashidi, J. Robert Kane, Deepak Kanojia, Maciej S. Lesniak

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gene therapy is a rapidly developing treatment modality that functions on its ability to deliver genes directly to the tumor site in order to yield antitumoral effects and thus prolong patient survival. The delivery of any gene(s) requires a delivery system that either involves the direct delivery of therapeutic gene(s) to the tumor site via viral or nonviral vectors, or through carriers that express the gene(s) in the tumor site via neural stem cells, mesenchymal stem cells, or other carriers. Four basic categories of gene therapy are currently being investigated for the treatment of brain tumors: (i) prodrug activation and suicide gene therapy; (ii) immunomodulatory and cytokine-based gene therapy; (iii) brain tumor hallmark targeting therapy; and (iv) oncolytic virotherapy. Preclinical studies of gene therapy for brain tumors have led to an array of human clinical trials, demonstrated to be remarkably safe and well tolerated with encouraging therapeutic results.

Original languageEnglish (US)
Title of host publicationHandbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
Subtitle of host publicationSecond Edition
PublisherElsevier Inc
Pages211-227
Number of pages17
ISBN (Print)9780128121009
DOIs
StatePublished - Apr 24 2018

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Keywords

  • Brain tumor hallmark targeting therapy
  • Gene delivery system
  • Gene therapy
  • Immunomodulatory gene therapy
  • Oncolytic virotherapy
  • Suicide gene therapy

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Kim, J. W., Pituch, K. C., Xiao, A., Young, J. S., Panek, W. K., Muroski, M. E., Rashidi, A., Kane, J. R., Kanojia, D., & Lesniak, M. S. (2018). Gene/Viral Treatment Approaches for Malignant Brain Cancer. In Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy: Second Edition (pp. 211-227). Elsevier Inc. https://doi.org/10.1016/B978-0-12-812100-9.00015-2