Genome scan for tourette disorder in affected-sibling-pair and multigenerational families

David Pauls*, D. Cath, P. Heutink, M. Grados, H. S. Singer, J. T. Walkup, C. Illmann, J. M. Scharf, S. Santangelo, S. E. Stewart, J. Platko, D. L. Pauls, N. J. Cox, M. M. Robertson, S. Service, D. Keen-Kim, C. Sabatti, N. Freimer, G. A. Rouleau, J. B. Riviere & 23 others S. Chouinard, F. Richer, P. Lesperance, Y. Dion, R. A. King, J. R. Kidd, A. J. Pakstis, J. F. Leckman, K. K. Kidd, G. Gericke, R. Kurlan, P. Como, D. Palumbo, A. Verkerk, B. A. Oostra, W. McMahon, M. Leppert, H. Coon, C. Mathews, P. Sandor, C. L. Barr, C. Betard, D. Zelenika

*Corresponding author for this work

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken for TD. The sample analyzed includes 238 nuclear families yielding 304 "independent" sibling pairs and 18 separate multigenerational families, for a total of 2,040 individuals. A whole-genome screen with the use of 390 microsatellite markers was completed. Analyses were completed using two diagnostic classifications: (1) only individuals with TD were included as affected and (2) individuals with either TD or chronic-tic (CT) disorder were included as affected. Strong evidence of linkage was observed for a region on chromosome 2p (- logP = 4.42, P = 3.8 × 10-5) in the analyses that included individuals with TD or CT disorder as affected. Results in several other regions also provide moderate evidence (- logP >2.0) of additional susceptibility loci for TD.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalAmerican Journal of Human Genetics
Volume80
Issue number2
DOIs
StatePublished - Jan 1 2007

Fingerprint

Tourette Syndrome
Siblings
Genome
Tic Disorders
Tics
Genetic Linkage
Nuclear Family
Microsatellite Repeats
Chromosomes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Pauls, David ; Cath, D. ; Heutink, P. ; Grados, M. ; Singer, H. S. ; Walkup, J. T. ; Illmann, C. ; Scharf, J. M. ; Santangelo, S. ; Stewart, S. E. ; Platko, J. ; Pauls, D. L. ; Cox, N. J. ; Robertson, M. M. ; Service, S. ; Keen-Kim, D. ; Sabatti, C. ; Freimer, N. ; Rouleau, G. A. ; Riviere, J. B. ; Chouinard, S. ; Richer, F. ; Lesperance, P. ; Dion, Y. ; King, R. A. ; Kidd, J. R. ; Pakstis, A. J. ; Leckman, J. F. ; Kidd, K. K. ; Gericke, G. ; Kurlan, R. ; Como, P. ; Palumbo, D. ; Verkerk, A. ; Oostra, B. A. ; McMahon, W. ; Leppert, M. ; Coon, H. ; Mathews, C. ; Sandor, P. ; Barr, C. L. ; Betard, C. ; Zelenika, D. / Genome scan for tourette disorder in affected-sibling-pair and multigenerational families. In: American Journal of Human Genetics. 2007 ; Vol. 80, No. 2. pp. 265-272.
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abstract = "Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken for TD. The sample analyzed includes 238 nuclear families yielding 304 {"}independent{"} sibling pairs and 18 separate multigenerational families, for a total of 2,040 individuals. A whole-genome screen with the use of 390 microsatellite markers was completed. Analyses were completed using two diagnostic classifications: (1) only individuals with TD were included as affected and (2) individuals with either TD or chronic-tic (CT) disorder were included as affected. Strong evidence of linkage was observed for a region on chromosome 2p (- logP = 4.42, P = 3.8 × 10-5) in the analyses that included individuals with TD or CT disorder as affected. Results in several other regions also provide moderate evidence (- logP >2.0) of additional susceptibility loci for TD.",
author = "David Pauls and D. Cath and P. Heutink and M. Grados and Singer, {H. S.} and Walkup, {J. T.} and C. Illmann and Scharf, {J. M.} and S. Santangelo and Stewart, {S. E.} and J. Platko and Pauls, {D. L.} and Cox, {N. J.} and Robertson, {M. M.} and S. Service and D. Keen-Kim and C. Sabatti and N. Freimer and Rouleau, {G. A.} and Riviere, {J. B.} and S. Chouinard and F. Richer and P. Lesperance and Y. Dion and King, {R. A.} and Kidd, {J. R.} and Pakstis, {A. J.} and Leckman, {J. F.} and Kidd, {K. K.} and G. Gericke and R. Kurlan and P. Como and D. Palumbo and A. Verkerk and Oostra, {B. A.} and W. McMahon and M. Leppert and H. Coon and C. Mathews and P. Sandor and Barr, {C. L.} and C. Betard and D. Zelenika",
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Pauls, D, Cath, D, Heutink, P, Grados, M, Singer, HS, Walkup, JT, Illmann, C, Scharf, JM, Santangelo, S, Stewart, SE, Platko, J, Pauls, DL, Cox, NJ, Robertson, MM, Service, S, Keen-Kim, D, Sabatti, C, Freimer, N, Rouleau, GA, Riviere, JB, Chouinard, S, Richer, F, Lesperance, P, Dion, Y, King, RA, Kidd, JR, Pakstis, AJ, Leckman, JF, Kidd, KK, Gericke, G, Kurlan, R, Como, P, Palumbo, D, Verkerk, A, Oostra, BA, McMahon, W, Leppert, M, Coon, H, Mathews, C, Sandor, P, Barr, CL, Betard, C & Zelenika, D 2007, 'Genome scan for tourette disorder in affected-sibling-pair and multigenerational families', American Journal of Human Genetics, vol. 80, no. 2, pp. 265-272. https://doi.org/10.1086/511052

Genome scan for tourette disorder in affected-sibling-pair and multigenerational families. / Pauls, David; Cath, D.; Heutink, P.; Grados, M.; Singer, H. S.; Walkup, J. T.; Illmann, C.; Scharf, J. M.; Santangelo, S.; Stewart, S. E.; Platko, J.; Pauls, D. L.; Cox, N. J.; Robertson, M. M.; Service, S.; Keen-Kim, D.; Sabatti, C.; Freimer, N.; Rouleau, G. A.; Riviere, J. B.; Chouinard, S.; Richer, F.; Lesperance, P.; Dion, Y.; King, R. A.; Kidd, J. R.; Pakstis, A. J.; Leckman, J. F.; Kidd, K. K.; Gericke, G.; Kurlan, R.; Como, P.; Palumbo, D.; Verkerk, A.; Oostra, B. A.; McMahon, W.; Leppert, M.; Coon, H.; Mathews, C.; Sandor, P.; Barr, C. L.; Betard, C.; Zelenika, D.

In: American Journal of Human Genetics, Vol. 80, No. 2, 01.01.2007, p. 265-272.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genome scan for tourette disorder in affected-sibling-pair and multigenerational families

AU - Pauls, David

AU - Cath, D.

AU - Heutink, P.

AU - Grados, M.

AU - Singer, H. S.

AU - Walkup, J. T.

AU - Illmann, C.

AU - Scharf, J. M.

AU - Santangelo, S.

AU - Stewart, S. E.

AU - Platko, J.

AU - Pauls, D. L.

AU - Cox, N. J.

AU - Robertson, M. M.

AU - Service, S.

AU - Keen-Kim, D.

AU - Sabatti, C.

AU - Freimer, N.

AU - Rouleau, G. A.

AU - Riviere, J. B.

AU - Chouinard, S.

AU - Richer, F.

AU - Lesperance, P.

AU - Dion, Y.

AU - King, R. A.

AU - Kidd, J. R.

AU - Pakstis, A. J.

AU - Leckman, J. F.

AU - Kidd, K. K.

AU - Gericke, G.

AU - Kurlan, R.

AU - Como, P.

AU - Palumbo, D.

AU - Verkerk, A.

AU - Oostra, B. A.

AU - McMahon, W.

AU - Leppert, M.

AU - Coon, H.

AU - Mathews, C.

AU - Sandor, P.

AU - Barr, C. L.

AU - Betard, C.

AU - Zelenika, D.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken for TD. The sample analyzed includes 238 nuclear families yielding 304 "independent" sibling pairs and 18 separate multigenerational families, for a total of 2,040 individuals. A whole-genome screen with the use of 390 microsatellite markers was completed. Analyses were completed using two diagnostic classifications: (1) only individuals with TD were included as affected and (2) individuals with either TD or chronic-tic (CT) disorder were included as affected. Strong evidence of linkage was observed for a region on chromosome 2p (- logP = 4.42, P = 3.8 × 10-5) in the analyses that included individuals with TD or CT disorder as affected. Results in several other regions also provide moderate evidence (- logP >2.0) of additional susceptibility loci for TD.

AB - Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken for TD. The sample analyzed includes 238 nuclear families yielding 304 "independent" sibling pairs and 18 separate multigenerational families, for a total of 2,040 individuals. A whole-genome screen with the use of 390 microsatellite markers was completed. Analyses were completed using two diagnostic classifications: (1) only individuals with TD were included as affected and (2) individuals with either TD or chronic-tic (CT) disorder were included as affected. Strong evidence of linkage was observed for a region on chromosome 2p (- logP = 4.42, P = 3.8 × 10-5) in the analyses that included individuals with TD or CT disorder as affected. Results in several other regions also provide moderate evidence (- logP >2.0) of additional susceptibility loci for TD.

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DO - 10.1086/511052

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