Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations

Nathan Pankratz, William C. Nichols, Sean K. Uniacke, Cheryl Halter, Alice Rudolph, Cliff Shults, P. Michael Conneally, Tatiana Foroud, Lawrence Golbe, William Koller, Karen Marder, Frederick Marshall, David Oakes, Aileen Shinaman, Eric Siemers, Julie Carter, Richard Camicioli, Pamela Andrews, Joanne Wojcieszek, Joann BeldenMagali Frenandez, Jean Hubble, Carson Reider, Ali Rajput, Alex Rajput, Theresa Shirley, Michael Panisset, Jean Hall, Tilak Mendis, David A. Grimes, Peggy Gray, Carmen Serrano Ramos, Sandra Roque, Stephen Reich, Becky Dunlop, Robert Hauser, Juan Sanchez-Ramos, Theresa Zesiewicz, Holly Delgado, Ronald Pfeiffer, Brenda Pfeiffer, Joseph Friedman, Hubert Fernandez, Margaret Lannon, Deborah Fontaine, Lauren Seeberger, Christopher O’brien, Deborah Judd, Rajesh Pahwa, Tanya Simuni, Parkinson Study Group

Research output: Contribution to journalArticlepeer-review

149 Scopus citations


Parkinson disease (PD) is a common neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity, and postural instability, as well as by a clinically significant response to treatment with levodopa. Mutations in the α-synuclein gene have been found to result in autosomal dominant PD, and mutations in the parkin gene produce autosomal recessive juvenile-onset PD. We have studied 203 sibling pairs with PD who were evaluated by a rigorous neurological assessment based on (a) inclusion criteria consisting of clinical features highly associated with autopsy-confirmed PD and (b) exclusion criteria highly associated with other, non-PD pathological diagnoses. Families with positive LOD scores for a marker in an intron of the parkin gene were prioritized for parkin-gene testing, and mutations in the parkin gene were identified in 22 families. To reduce genetic heterogeneity, these families were not included in subsequent genome-screen analysis. Thus, a total of 160 multiplex families without evidence of a parkin mutation were used in multipoint nonparametric linkage analysis to identify PD-susceptibility genes. Two models of PD affection status were considered: model I included only those individuals with a more stringent diagnosis of verified PD (96 sibling pairs from 90 families), whereas model II included all examined individuals as affected, regardless of their final diagnostic classification (170 sibling pairs from 160 families). Under model I, the highest LOD scores were observed on chromosome X (LOD score 2.1) and on chromosome 2 (LOD score 1.9). Analyses performed with all available sibling pairs (model II) found even greater evidence of linkage to chromosome X (LOD score 2.7) and to chromosome 2 (LOD score 2.5). Evidence of linkage was also found to chromosomes 4, 5, and 13 (LOD scores >1.5). Our findings are consistent with those of other linkage studies that have reported linkage to chromosomes 5 and X.

Original languageEnglish (US)
Pages (from-to)124-135
Number of pages12
JournalAmerican journal of human genetics
Issue number1
StatePublished - 2002

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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