Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis

Natalia Ivanova*, Alexei Sorokin, Iain Anderson, Nathalie Galleron, Benjamin Candelon, Vinayak Kapatral, Anamitra Bhattacharyya, Gary Reznik, Natalia Mikhailova, Alla Lapidus, Lien Chu, Michael Mazur, Eugene Goltsman, Niels Larsen, Mark D'Souza, Theresa Walunas, Yuri Grechkin, Gordon Pusch, Robert Haselkorn, Michael FonsteinS. Dusko Ehrlich, Ross Overbeek, Nikos Kyrpides

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

620 Scopus citations

Abstract

Bacillus cereus is an opportunistic pathogen causing food poisoning manifested by diarrhoeal or emetic syndromes. It is closely related to the animal and human pathogen Bacillus anthracis and the insect pathogen Bacillus thuringiensis, the former being used as a biological weapon and the latter as a pesticide. B. anthracis and B. thuringiensis are readily distinguished from B. cereus by the presence of plasmid-borne specific toxins (B. anthracis and B. thuringiensis) and capsule (B. anthracis). But phylogenetic studies based on the analysis of chromosomal genes bring controversial results, and it is unclear whether B. cereus, B. anthracis and B. thuringiensis are varieties of the same species or different species. Here we report the sequencing and analysis of the type strain B. cereus ATCC 14579. The complete genome sequence of B. cereus ATCC 14579 together with the gapped genome of B. anthracis A2012 enables us to perform comparative analysis, and hence to identify the genes that are conserved between B. cereus and B. anthracis, and the genes that are unique for each species. We use the former to clarify the phylogeny of the cereus group, and the latter to determine plasmid-independent species-specific markers.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalNature
Volume423
Issue number6935
DOIs
StatePublished - 2003

ASJC Scopus subject areas

  • General

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