TY - JOUR
T1 - Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
AU - Gudmundsson, Julius
AU - Sulem, Patrick
AU - Gudbjartsson, Daniel F.
AU - Blondal, Thorarinn
AU - Gylfason, Arnaldur
AU - Agnarsson, Bjarni A.
AU - Benediktsdottir, Kristrun R.
AU - Magnusdottir, Droplaug N.
AU - Orlygsdottir, Gudbjorg
AU - Jakobsdottir, Margret
AU - Stacey, Simon N.
AU - Sigurdsson, Asgeir
AU - Wahlfors, Tiina
AU - Tammela, Teuvo
AU - Breyer, Joan P.
AU - McReynolds, Kate M.
AU - Bradley, Kevin M.
AU - Saez, Berta
AU - Godino, Javier
AU - Navarrete, Sebastian
AU - Fuertes, Fernando
AU - Murillo, Laura
AU - Polo, Eduardo
AU - Aben, Katja K.
AU - Van Oort, Inge M.
AU - Suarez, Brian K.
AU - Helfand, Brian T.
AU - Kan, Donghui
AU - Zanon, Carlo
AU - Frigge, Michael L.
AU - Kristjansson, Kristleifur
AU - Gulcher, Jeffrey R.
AU - Einarsson, Gudmundur V.
AU - Jonsson, Eirikur
AU - Catalona, William J.
AU - Mayordomo, Jose I.
AU - Kiemeney, Lambertus A.
AU - Smith, Jeffrey R.
AU - Schleutker, Johanna
AU - Barkardottir, Rosa B.
AU - Kong, Augustine
AU - Thorsteinsdottir, Unnur
AU - Rafnar, Thorunn
AU - Stefansson, Kari
N1 - Funding Information:
We thank the individuals who participated in the study and whose contribution made this work possible. This project was funded in part by contract number 202059 (PROMARK) from the Seventh Framework Program of the European Union to deCODE Genetics (T.R. and L.A.K.), in part by FP7-MC-IAPP Grant agreement no. 218071 (CancerGene) to deCODE Genetics, in part by a V Foundation award and US Department of Veterans Affairs grants to J.R.S., and in part by Academy of Finland, Sigrid Juselius Foundation, Finnish Cancer Organisations and the Competitive Research Funding of the Pirkanmaa Hospital District, Tampere University Hospital, to J.S.
PY - 2009/10
Y1 - 2009/10
N2 - We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 × 1010) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 × 1015) and rs445114[T] (OR = 1.14, P = 4.7 × 1010), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 × 1011) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 × 1012). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.
AB - We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 × 1010) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 × 1015) and rs445114[T] (OR = 1.14, P = 4.7 × 1010), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 × 1011) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 × 1012). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.
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U2 - 10.1038/ng.448
DO - 10.1038/ng.448
M3 - Article
C2 - 19767754
AN - SCOPUS:70349547128
SN - 1061-4036
VL - 41
SP - 1122
EP - 1126
JO - Nature Genetics
JF - Nature Genetics
IS - 10
ER -
