Genome-wide association study of personality traits in bipolar patients

Ney Alliey-Rodriguez*, Dandan Zhang, Judith A. Badner, Benjamin B. Lahey, Xiaotong Zhang, Stephen Dinwiddie, Benjamin Romanos, Natalie Plenys, Chunyu Liu, Elliot S. Gershon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


OBJECTIVE: Genome-wide association study was carried out on personality traits among bipolar patients as possible endophenotypes for gene discovery in bipolar disorder. METHODS: The subscales of Cloninger's Temperament and Character Inventory (TCI) and the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ) were used as quantitative phenotypes. The genotyping platform was the Affymetrix 6.0 SNP array. The sample consisted of 944 individuals for TCI and 1007 for ZKPQ, all of European ancestry, diagnosed with bipolar disorder by Diagnostic and Statistical Manual of Mental Disorders-IV criteria. RESULTS: Genome-wide significant association was found for two subscales of the TCI, rs10479334 with the 'Social Acceptance versus Social Intolerance' subscale (Bonferroni P=0.014) in an intergenic region, and rs9419788 with the 'Spiritual Acceptance versus Rational Materialism' subscale (Bonferroni P=0.036) in PLCE1 gene. Although genome-wide significance was not reached for ZKPQ scales, lowest P values pinpointed to genes, RXRG for Sensation Seeking, GRM7 and ITK for Neuroticism Anxiety, and SPTLC3 gene for Aggression Hostility. CONCLUSION: After correction for the 25 subscales in TCI and four scales plus two subscales in ZKPQ, phenotype-wide significance was not reached.

Original languageEnglish (US)
Pages (from-to)190-194
Number of pages5
JournalPsychiatric Genetics
Issue number4
StatePublished - Aug 2011


  • GRM7
  • RXRG
  • Temperament and Character Inventory
  • Zuckerman-Kuhlman Personality Questionnaire
  • bipolar
  • genome-wide association study
  • personality

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry


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