Genome-wide identification of conserved longevity genes in yeast and worms

Erica D. Smith, Brian K. Kennedy*, Matt Kaeberlein

*Corresponding author for this work

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Technological advancements in invertebrate model organisms have recently made it possible to survey many or all of the genes in the genome for phenotypes of interest. In both C. elegans and S. cerevisiae, genome-wide searches for hypomorphic mutations that extend life span have been performed. The results from these screens are starting to provide a more complete view of the range of life span determinants in eukaryotes. In addition, it is becoming possible to test the premise that conserved aging genes and pathways regulate aging in disparate eukaryotic species. Here we compare and contrast the results from genome-wide aging screens and assess the likelihood that there are "public" aging mechanisms.

Original languageEnglish (US)
Pages (from-to)106-111
Number of pages6
JournalMechanisms of Ageing and Development
Volume128
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Calorie restriction
  • Chronological life span
  • Genomics
  • RNAi
  • Replicative life span

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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