Genome-wide identification of conserved longevity genes in yeast and worms

Erica D. Smith; Brian K. Kennedy; Matt Kaeberlein

doi:10.1016/j.mad.2006.11.017

Genome-wide identification of conserved longevity genes in yeast and worms

Erica D. Smith, Brian K. Kennedy^*, Matt Kaeberlein

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Technological advancements in invertebrate model organisms have recently made it possible to survey many or all of the genes in the genome for phenotypes of interest. In both C. elegans and S. cerevisiae, genome-wide searches for hypomorphic mutations that extend life span have been performed. The results from these screens are starting to provide a more complete view of the range of life span determinants in eukaryotes. In addition, it is becoming possible to test the premise that conserved aging genes and pathways regulate aging in disparate eukaryotic species. Here we compare and contrast the results from genome-wide aging screens and assess the likelihood that there are "public" aging mechanisms.

Original language	English (US)
Pages (from-to)	106-111
Number of pages	6
Journal	Mechanisms of Ageing and Development
Volume	128
Issue number	1
DOIs	https://doi.org/10.1016/j.mad.2006.11.017
State	Published - Jan 2007

Keywords

Calorie restriction
Chronological life span
Genomics
RNAi
Replicative life span

ASJC Scopus subject areas

Aging
Developmental Biology

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10.1016/j.mad.2006.11.017

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title = "Genome-wide identification of conserved longevity genes in yeast and worms",

abstract = "Technological advancements in invertebrate model organisms have recently made it possible to survey many or all of the genes in the genome for phenotypes of interest. In both C. elegans and S. cerevisiae, genome-wide searches for hypomorphic mutations that extend life span have been performed. The results from these screens are starting to provide a more complete view of the range of life span determinants in eukaryotes. In addition, it is becoming possible to test the premise that conserved aging genes and pathways regulate aging in disparate eukaryotic species. Here we compare and contrast the results from genome-wide aging screens and assess the likelihood that there are {"}public{"} aging mechanisms.",

keywords = "Calorie restriction, Chronological life span, Genomics, RNAi, Replicative life span",

author = "Smith, {Erica D.} and Kennedy, {Brian K.} and Matt Kaeberlein",

note = "Funding Information: Longevity studies aimed at finding conserved longevity determinants are funded by a grant to B.K.K. and M.K. from the Ellison Medical Foundation, a research grant to M.K. from the American Federation for Aging Research, and by NIH Grant R01 AG024287 to B.K.K. Additional support is provided by the University of Washington Nathan Shock Center of Excellence for the Basic Biology of Aging. E.D.S. is supported by NIH training grant P30 AG013280. ",

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AU - Kennedy, Brian K.

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KW - Chronological life span

KW - Genomics

KW - RNAi

KW - Replicative life span

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Genome-wide identification of conserved longevity genes in yeast and worms

Abstract

Keywords

ASJC Scopus subject areas

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