Abstract
Technological advancements in invertebrate model organisms have recently made it possible to survey many or all of the genes in the genome for phenotypes of interest. In both C. elegans and S. cerevisiae, genome-wide searches for hypomorphic mutations that extend life span have been performed. The results from these screens are starting to provide a more complete view of the range of life span determinants in eukaryotes. In addition, it is becoming possible to test the premise that conserved aging genes and pathways regulate aging in disparate eukaryotic species. Here we compare and contrast the results from genome-wide aging screens and assess the likelihood that there are "public" aging mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 106-111 |
| Number of pages | 6 |
| Journal | Mechanisms of Ageing and Development |
| Volume | 128 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2007 |
Funding
Longevity studies aimed at finding conserved longevity determinants are funded by a grant to B.K.K. and M.K. from the Ellison Medical Foundation, a research grant to M.K. from the American Federation for Aging Research, and by NIH Grant R01 AG024287 to B.K.K. Additional support is provided by the University of Washington Nathan Shock Center of Excellence for the Basic Biology of Aging. E.D.S. is supported by NIH training grant P30 AG013280.
Keywords
- Calorie restriction
- Chronological life span
- Genomics
- RNAi
- Replicative life span
ASJC Scopus subject areas
- Aging
- Developmental Biology