Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer

Matthias D. Hofer, Rainer Kuefer, Christiane Maier, Kathleen Herkommer, Sven Perner, Francesca Demichelis, Thomas Paiss, Walter Vogel, Mark A. Rubin, Josef Hoegel

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22 Scopus citations

Abstract

Fusion of the 5′-untranslated region of androgen-regulated TMPRSS2 promoter with ETS transcription factor family members is found frequently in prostate cancers, and recent work suggests that the most common TMPRSS2-ERG fusion is associated with an aggressive clinical phenotype compared with fusion-negative prostate cancer. Thus far, analysis of the fusion has been limited to sporadic cases of prostate cancer. In the current study, we explore for an enrichment of TMPRSS2-ERG fusion in familial prostate cancer. TMPRSS2-ERG fusion was identified using a break-apart fluorescence in situ hybridization assay on tissue microarrays. Presence of TMPRSS2-ERG fusion was associated with higher Gleason scores (P = 0.027). Of 75 patients with established history of prostate cancer, we detected the TMPRSS2-ERG fusion in 44 (59%) patients. Almost three quarters (73%) of fusion-positive patients accumulated within 16 specific families whereas only 27% were single fusion-positive cases within one family. Based on reported prevalence rates, we calculated a sibling recurrence risk ratio of up to 18.9. A subset (63%) of families with uniformly TMPRSS2-ERG-positive prostate cancer underwent a genome-wide linkage scan at 500 markers. This revealed several loci located on chromosomes #9, #18, and X that were suggestive of linkage to the TMPRSS2-ERG fusion-positive prostate cancer phenotype with linkage-of-disease scores up to 2.16 and nonparametric linkage scores up to 2.77. This suggests the presence of an inherited susceptibility to developing the TMPRSS2-ERG fusion. Given the association of TMPRSS2-ERG fusion and aggressive prostate cancer, close surveillance of relatives of patients with established fusion-positive prostate cancer or a family history of prostate cancer in general would be warranted.

Original languageEnglish (US)
Pages (from-to)640-646
Number of pages7
JournalCancer Research
Volume69
Issue number2
DOIs
StatePublished - Jan 15 2009

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Hofer, M. D., Kuefer, R., Maier, C., Herkommer, K., Perner, S., Demichelis, F., Paiss, T., Vogel, W., Rubin, M. A., & Hoegel, J. (2009). Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer. Cancer Research, 69(2), 640-646. https://doi.org/10.1158/0008-5472.CAN-08-2008