Genome-wide scan demonstrates significant linkage for male sexual orientation

A. R. Sanders; E. R. Martin; G. W. Beecham; S. Guo; K. Dawood; G. Rieger; J. A. Badner; E. S. Gershon; R. S. Krishnappa; A. B. Kolundzija; J. Duan; P. V. Gejman; J. M. Bailey

doi:10.1017/S0033291714002451

Genome-wide scan demonstrates significant linkage for male sexual orientation

A. R. Sanders^*, E. R. Martin, G. W. Beecham, S. Guo, K. Dawood, G. Rieger, J. A. Badner, E. S. Gershon, R. S. Krishnappa, A. B. Kolundzija, J. Duan, P. V. Gejman, J. M. Bailey

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Background Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. Method We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date. Results We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research. Conclusions Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.

Original language	English (US)
Pages (from-to)	1379-1388
Number of pages	10
Journal	Psychological Medicine
Volume	45
Issue number	7
DOIs	https://doi.org/10.1017/S0033291714002451
State	Published - May 28 2015

Keywords

Chromosome 8
chromosome Xq28
complex trait
genome-wide linkage scan
human
male sexual orientation.

ASJC Scopus subject areas

Psychiatry and Mental health
Applied Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S0033291714002451

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title = "Genome-wide scan demonstrates significant linkage for male sexual orientation",

abstract = "Background Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. Method We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date. Results We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research. Conclusions Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.",

keywords = "Chromosome 8, chromosome Xq28, complex trait, genome-wide linkage scan, human, male sexual orientation.",

author = "Sanders, {A. R.} and Martin, {E. R.} and Beecham, {G. W.} and S. Guo and K. Dawood and G. Rieger and Badner, {J. A.} and Gershon, {E. S.} and Krishnappa, {R. S.} and Kolundzija, {A. B.} and J. Duan and Gejman, {P. V.} and Bailey, {J. M.}",

note = "Publisher Copyright: Copyright {\textcopyright} Cambridge University Press 2014.",

year = "2015",

month = may,

day = "28",

doi = "10.1017/S0033291714002451",

language = "English (US)",

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T1 - Genome-wide scan demonstrates significant linkage for male sexual orientation

AU - Sanders, A. R.

AU - Martin, E. R.

AU - Beecham, G. W.

AU - Guo, S.

AU - Dawood, K.

AU - Rieger, G.

AU - Badner, J. A.

AU - Gershon, E. S.

AU - Krishnappa, R. S.

AU - Kolundzija, A. B.

AU - Duan, J.

AU - Gejman, P. V.

AU - Bailey, J. M.

PY - 2015/5/28

Y1 - 2015/5/28

N2 - Background Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. Method We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date. Results We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research. Conclusions Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.

AB - Background Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. Method We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date. Results We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research. Conclusions Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.

KW - Chromosome 8

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KW - genome-wide linkage scan

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Genome-wide scan demonstrates significant linkage for male sexual orientation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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