Genomic aberrations in myeloid sarcoma without blood or bone marrow involvement: Characterization of formalin-fixed paraffin-embedded samples by chromosomal microarrays

M. Kamran Mirza, Madina Sukhanova, Friedrich Stölzel, Kenan Onel, Richard A. Larson, Wendy Stock, Gerhard Ehninger, Friederike Kuithan, Klaus Zöphel, Poluru Reddy, Loren Joseph, Gordana Raca*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Myeloid sarcoma (MS) is a presentation of acute myeloid leukemia (AML) as a tumor mass outside of the bone marrow. Viable cells from MS are frequently unavailable for cytogenetic studies. We therefore investigated whether chromosomal microarray analysis (CMA) using formalin-fixed paraffin-embedded (FFPE) tissues can detect clinically important genetic abnormalities in MS. CMA successfully identified genomic aberrations in six cases of MS, and in two cases it revealed multiple abnormalities equivalent to a complex karyotype, thus predicting a poor outcome. CMA using FFPE material is therefore a feasible and clinically applicable approach for detection of prognostically significant genomic abnormalities in MS.

Original languageEnglish (US)
Pages (from-to)1091-1096
Number of pages6
JournalLeukemia Research
Volume38
Issue number9
DOIs
StatePublished - Sep 2014

Keywords

  • Chromosomal microarrays
  • Cytogenetics
  • Myeloid sarcoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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