Genomic alterations in distal bile duct carcinoma by comparative genomic hybridization and karyotype analysis

Arjen M. Rijken, Jie Hu, Elizabeth J. Perlman, Laura A. Morsberger, Patricia Long, Scott E. Kern, Ralph H. Hruban, Charles J. Yeo, Constance A. Griffin*

*Corresponding author for this work

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

We report genomic abnormalities identified in 14 human primary common bile duct carcinomas analyzed by cytogenetics or comparative genomic hybridization, or both. Combining the results of the two methods of analysis, 11 chromosomal arms were observed to be gained in whole or in part, and 9 chromosomal arms were lost in whole or in part in at least four tumors each. The most frequently lost chromosomal regions were, in decreasing order: 18q (eight tumors); 6q and 10p (seven tumors each); 8p, 12q, and 17p (six tumors each); and 7q, 12p, and 22q (four tumors each). The most frequently gained regions were 8q and 20q (six tumors each); 12p, 17q, and Xp (five tumors each); and 2q, 6p, 7p, 11q, 13q, and 19q (four tumors each). These results are similar to those we have previously reported in pancreatic cancer and suggest that carcinomas of the common bile duct and pancreas share a number of genetic changes.

Original languageEnglish (US)
Pages (from-to)185-191
Number of pages7
JournalGenes Chromosomes and Cancer
Volume26
Issue number3
DOIs
StatePublished - Nov 1 1999

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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