Non-coding regions of the human genome contain vast regulatory potential that contributes to the coordination of gene expression. Indeed, regulatory elements can reside large genomic distances from the promoters of genes they control. Here we describe approaches recently used to identify functional elements within the complex CFTR locus.
|Original language||English (US)|
|Number of pages||5|
|State||Published - 2011|
- Chromosome conformation capture (3C)
- DNase I hypersensitivity
- Tissue-specific enhancers
ASJC Scopus subject areas