Genomic approaches for the discovery of CFTR regulatory elements

Christopher J. Ott, Ann Harris*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Non-coding regions of the human genome contain vast regulatory potential that contributes to the coordination of gene expression. Indeed, regulatory elements can reside large genomic distances from the promoters of genes they control. Here we describe approaches recently used to identify functional elements within the complex CFTR locus.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalTranscription
Volume2
Issue number1
DOIs
StatePublished - 2011

Keywords

  • CFTR
  • Chromosome conformation capture (3C)
  • DNase I hypersensitivity
  • DNase-chip
  • Tissue-specific enhancers

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

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