Genomic approaches for the discovery of CFTR regulatory elements

Christopher J. Ott; Ann Harris

doi:10.4161/trns.2.1.13693

Genomic approaches for the discovery of CFTR regulatory elements

Christopher J. Ott, Ann Harris^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Non-coding regions of the human genome contain vast regulatory potential that contributes to the coordination of gene expression. Indeed, regulatory elements can reside large genomic distances from the promoters of genes they control. Here we describe approaches recently used to identify functional elements within the complex CFTR locus.

Original language	English (US)
Pages (from-to)	23-27
Number of pages	5
Journal	Transcription
Volume	2
Issue number	1
DOIs	https://doi.org/10.4161/trns.2.1.13693
State	Published - 2011

Keywords

CFTR
Chromosome conformation capture (3C)
DNase I hypersensitivity
DNase-chip
Tissue-specific enhancers

ASJC Scopus subject areas

Genetics
Biochemistry
Biotechnology

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10.4161/trns.2.1.13693

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title = "Genomic approaches for the discovery of CFTR regulatory elements",

abstract = "Non-coding regions of the human genome contain vast regulatory potential that contributes to the coordination of gene expression. Indeed, regulatory elements can reside large genomic distances from the promoters of genes they control. Here we describe approaches recently used to identify functional elements within the complex CFTR locus.",

keywords = "CFTR, Chromosome conformation capture (3C), DNase I hypersensitivity, DNase-chip, Tissue-specific enhancers",

author = "Ott, {Christopher J.} and Ann Harris",

note = "Funding Information: We thank Drs. N.P. Blackledge and M.A. Lewandowska for their contributions. This work was funded in part by NIH R01 HL094585 and the Cystic Fibrosis Foundation (USA).",

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AU - Ott, Christopher J.

AU - Harris, Ann

N1 - Funding Information: We thank Drs. N.P. Blackledge and M.A. Lewandowska for their contributions. This work was funded in part by NIH R01 HL094585 and the Cystic Fibrosis Foundation (USA).

PY - 2011

Y1 - 2011

N2 - Non-coding regions of the human genome contain vast regulatory potential that contributes to the coordination of gene expression. Indeed, regulatory elements can reside large genomic distances from the promoters of genes they control. Here we describe approaches recently used to identify functional elements within the complex CFTR locus.

AB - Non-coding regions of the human genome contain vast regulatory potential that contributes to the coordination of gene expression. Indeed, regulatory elements can reside large genomic distances from the promoters of genes they control. Here we describe approaches recently used to identify functional elements within the complex CFTR locus.

KW - CFTR

KW - Chromosome conformation capture (3C)

KW - DNase I hypersensitivity

KW - DNase-chip

KW - Tissue-specific enhancers

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JF - Transcription

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ER -

Genomic approaches for the discovery of CFTR regulatory elements

Abstract

Keywords

ASJC Scopus subject areas

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