Genomic landscape of cutaneous T cell lymphoma

Jaehyuk Choi, Gerald Goh, Trent Walradt, Bok S. Hong, Christopher G. Bunick, Kan Chen, Robert D. Bjornson, Yaakov Maman, Tiffany Wang, Jesse Tordoff, Kacie Carlson, John D. Overton, Kristina J. Liu, Julia M. Lewis, Lesley Devine, Lisa Barbarotta, Francine M. Foss, Antonio Subtil, Eric C. Vonderheid, Richard L. EdelsonDavid G. Schatz, Titus J. Boggon, Michael Girardi, Richard P. Lifton*

*Corresponding author for this work

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole-genome DNA sequencing and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NF-ΰ B signaling, chromatin remodeling and DNA damage response. CTCL is distinctive in that somatic copy number variants (SCNVs) comprise 92% of all driver mutations (mean of 11.8 pathogenic SCNVs versus 1.0 somatic single-nucleotide variant per CTCL). These findings have implications for new therapeutics.

Original languageEnglish (US)
Pages (from-to)1011-1019
Number of pages9
JournalNature Genetics
Volume47
Issue number9
DOIs
StatePublished - Aug 27 2015

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Cutaneous T-Cell Lymphoma
Exome
RNA Sequence Analysis
T-Lymphocytes
Mutation
Chromatin Assembly and Disassembly
DNA Sequence Analysis
Non-Hodgkin's Lymphoma
Genes
DNA Damage
Nucleotides
Genome
Apoptosis
Skin

ASJC Scopus subject areas

  • Genetics

Cite this

Choi, J., Goh, G., Walradt, T., Hong, B. S., Bunick, C. G., Chen, K., ... Lifton, R. P. (2015). Genomic landscape of cutaneous T cell lymphoma. Nature Genetics, 47(9), 1011-1019. https://doi.org/10.1038/ng.3356
Choi, Jaehyuk ; Goh, Gerald ; Walradt, Trent ; Hong, Bok S. ; Bunick, Christopher G. ; Chen, Kan ; Bjornson, Robert D. ; Maman, Yaakov ; Wang, Tiffany ; Tordoff, Jesse ; Carlson, Kacie ; Overton, John D. ; Liu, Kristina J. ; Lewis, Julia M. ; Devine, Lesley ; Barbarotta, Lisa ; Foss, Francine M. ; Subtil, Antonio ; Vonderheid, Eric C. ; Edelson, Richard L. ; Schatz, David G. ; Boggon, Titus J. ; Girardi, Michael ; Lifton, Richard P. / Genomic landscape of cutaneous T cell lymphoma. In: Nature Genetics. 2015 ; Vol. 47, No. 9. pp. 1011-1019.
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Choi, J, Goh, G, Walradt, T, Hong, BS, Bunick, CG, Chen, K, Bjornson, RD, Maman, Y, Wang, T, Tordoff, J, Carlson, K, Overton, JD, Liu, KJ, Lewis, JM, Devine, L, Barbarotta, L, Foss, FM, Subtil, A, Vonderheid, EC, Edelson, RL, Schatz, DG, Boggon, TJ, Girardi, M & Lifton, RP 2015, 'Genomic landscape of cutaneous T cell lymphoma', Nature Genetics, vol. 47, no. 9, pp. 1011-1019. https://doi.org/10.1038/ng.3356

Genomic landscape of cutaneous T cell lymphoma. / Choi, Jaehyuk; Goh, Gerald; Walradt, Trent; Hong, Bok S.; Bunick, Christopher G.; Chen, Kan; Bjornson, Robert D.; Maman, Yaakov; Wang, Tiffany; Tordoff, Jesse; Carlson, Kacie; Overton, John D.; Liu, Kristina J.; Lewis, Julia M.; Devine, Lesley; Barbarotta, Lisa; Foss, Francine M.; Subtil, Antonio; Vonderheid, Eric C.; Edelson, Richard L.; Schatz, David G.; Boggon, Titus J.; Girardi, Michael; Lifton, Richard P.

In: Nature Genetics, Vol. 47, No. 9, 27.08.2015, p. 1011-1019.

Research output: Contribution to journalArticle

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T1 - Genomic landscape of cutaneous T cell lymphoma

AU - Choi, Jaehyuk

AU - Goh, Gerald

AU - Walradt, Trent

AU - Hong, Bok S.

AU - Bunick, Christopher G.

AU - Chen, Kan

AU - Bjornson, Robert D.

AU - Maman, Yaakov

AU - Wang, Tiffany

AU - Tordoff, Jesse

AU - Carlson, Kacie

AU - Overton, John D.

AU - Liu, Kristina J.

AU - Lewis, Julia M.

AU - Devine, Lesley

AU - Barbarotta, Lisa

AU - Foss, Francine M.

AU - Subtil, Antonio

AU - Vonderheid, Eric C.

AU - Edelson, Richard L.

AU - Schatz, David G.

AU - Boggon, Titus J.

AU - Girardi, Michael

AU - Lifton, Richard P.

PY - 2015/8/27

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Choi J, Goh G, Walradt T, Hong BS, Bunick CG, Chen K et al. Genomic landscape of cutaneous T cell lymphoma. Nature Genetics. 2015 Aug 27;47(9):1011-1019. https://doi.org/10.1038/ng.3356