Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer

Pamela L. Paris, Matthias D. Hofer, Giancarlo Albo, Rainer Kuefer, Juergen E. Gschwend, Richard E. Hautmann, Jane Fridyland, Jeffrey Simko, Peter R. Carroll, Mark A. Rubin, Colin Collins*

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The progression of organ-confined prostate cancer to metastatic cancer is inevitably fatal. Consequently, identification of structural changes in the genome and associated transcriptional responses that drive this progression is critical to understanding the disease process and the development of biomarkers and therapeutic targets. In this study, whole genome copy number changes in genomes of hormone-naïve lymph node metastases were profiled using array comparative genomic hybridization, and matched primaries were included for a subset. Matched primaries and lymph node metastases showed very similar copy number profiles that are distinct from primary tumors that fail to metastasize.

Original languageEnglish (US)
Pages (from-to)1083-1089
Number of pages7
JournalNeoplasia
Volume8
Issue number12
DOIs
StatePublished - Dec 2006

Keywords

  • Biomarkers
  • Lymph nodes
  • Metastases
  • Prostate cancer
  • aCGH

ASJC Scopus subject areas

  • Cancer Research

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    Paris, P. L., Hofer, M. D., Albo, G., Kuefer, R., Gschwend, J. E., Hautmann, R. E., Fridyland, J., Simko, J., Carroll, P. R., Rubin, M. A., & Collins, C. (2006). Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer. Neoplasia, 8(12), 1083-1089. https://doi.org/10.1593/neo.06421