Geometric control of cell life and death

Christopher S. Chen, Milan Mrksich, Sui Huang, George M. Whitesides, Donald E. Ingber*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3979 Scopus citations

Abstract

Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension. Cell spreading also was varied while maintaining the total cell-matrix contact area constant by changing the spacing between multiple focal adhesion-sized islands. Cell shape was found to govern whether individual cells grow or die, regardless of the type of matrix protein or antibody to integrin used to mediate adhesion. Local geometric control of cell growth and viability may therefore represent a fundamental mechanism for developmental regulation within the tissue microenvironment.

Original languageEnglish (US)
Pages (from-to)1425-1428
Number of pages4
JournalScience
Volume276
Issue number5317
DOIs
StatePublished - May 30 1997

ASJC Scopus subject areas

  • General

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