Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients

Lori S. Muffly, Masha Kocherginsky, Wendy Stock, Quynh Chu, Michael R. Bishop, Lucy A. Godley, Justin Kline, Hongtao Liu, Olatoyosi M. Odenike, Richard A. Larson, Koen van Besien, Andrew S. Artz

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Allogeneic hematopoietic cell transplantation is increasingly utilized in older adults. This study prospectively evaluated the prognostic utility of geriatric assessment domains prior to allogeneic transplantation in recipients aged 50 years and over. Geriatric assessment was performed prior to transplant, and included validated measures across domains of function and disability, comorbidity, frailty, mental health, nutritional status, and systemic inflammation. A total of 203 patients completed geriatric assessment and underwent transplant. Median age was 58 years (range 50-73). After adjusting for established prognostic factors, limitations in instrumental activities of daily living (HR 2.38, 95%CI: 1.59-3.56; P<0.001), slow walk speed (HR 1.80, 95%CI: 1.14-2.83; P=0.01), high comorbidity by hematopoietic cell transplantation-specific comorbidity index (HR 1.56, 95%CI: 1.07-2.28; P=0.02), low mental health by short-form-36 mental component summary (HR 1.67, 95%CI: 1.13-2.48; P=0.01), and elevated serum C-reactive protein (HR 2.51, 95%CI: 1.54-4.09; P<0.001) were significantly associated with inferior overall survival. These associations were more pronounced in the cohort 60 years and over. Geriatric assessment measures confer independent prognostic utility in older allogeneic transplant recipients. Implementation of geriatric assessment prior to allogeneic transplantation may aid appropriate selection of older adults.

Original languageEnglish (US)
Pages (from-to)1373-1379
Number of pages7
JournalHaematologica
Volume99
Issue number8
DOIs
StatePublished - Aug 1 2014

Fingerprint

Geriatric Assessment
Cell Transplantation
Survival
Comorbidity
Homologous Transplantation
Mental Health
Transplants
Activities of Daily Living
Nutritional Status
C-Reactive Protein
Health Status
Blood Proteins
Inflammation

ASJC Scopus subject areas

  • Hematology

Cite this

Muffly, Lori S. ; Kocherginsky, Masha ; Stock, Wendy ; Chu, Quynh ; Bishop, Michael R. ; Godley, Lucy A. ; Kline, Justin ; Liu, Hongtao ; Odenike, Olatoyosi M. ; Larson, Richard A. ; van Besien, Koen ; Artz, Andrew S. / Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients. In: Haematologica. 2014 ; Vol. 99, No. 8. pp. 1373-1379.
@article{0ed5a50acae14a4cac23c3271a197344,
title = "Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients",
abstract = "Allogeneic hematopoietic cell transplantation is increasingly utilized in older adults. This study prospectively evaluated the prognostic utility of geriatric assessment domains prior to allogeneic transplantation in recipients aged 50 years and over. Geriatric assessment was performed prior to transplant, and included validated measures across domains of function and disability, comorbidity, frailty, mental health, nutritional status, and systemic inflammation. A total of 203 patients completed geriatric assessment and underwent transplant. Median age was 58 years (range 50-73). After adjusting for established prognostic factors, limitations in instrumental activities of daily living (HR 2.38, 95{\%}CI: 1.59-3.56; P<0.001), slow walk speed (HR 1.80, 95{\%}CI: 1.14-2.83; P=0.01), high comorbidity by hematopoietic cell transplantation-specific comorbidity index (HR 1.56, 95{\%}CI: 1.07-2.28; P=0.02), low mental health by short-form-36 mental component summary (HR 1.67, 95{\%}CI: 1.13-2.48; P=0.01), and elevated serum C-reactive protein (HR 2.51, 95{\%}CI: 1.54-4.09; P<0.001) were significantly associated with inferior overall survival. These associations were more pronounced in the cohort 60 years and over. Geriatric assessment measures confer independent prognostic utility in older allogeneic transplant recipients. Implementation of geriatric assessment prior to allogeneic transplantation may aid appropriate selection of older adults.",
author = "Muffly, {Lori S.} and Masha Kocherginsky and Wendy Stock and Quynh Chu and Bishop, {Michael R.} and Godley, {Lucy A.} and Justin Kline and Hongtao Liu and Odenike, {Olatoyosi M.} and Larson, {Richard A.} and {van Besien}, Koen and Artz, {Andrew S.}",
year = "2014",
month = "8",
day = "1",
doi = "10.3324/haematol.2014.103655",
language = "English (US)",
volume = "99",
pages = "1373--1379",
journal = "Haematologica",
issn = "0390-6078",
publisher = "Ferrata Storti Foundation",
number = "8",

}

Muffly, LS, Kocherginsky, M, Stock, W, Chu, Q, Bishop, MR, Godley, LA, Kline, J, Liu, H, Odenike, OM, Larson, RA, van Besien, K & Artz, AS 2014, 'Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients', Haematologica, vol. 99, no. 8, pp. 1373-1379. https://doi.org/10.3324/haematol.2014.103655

Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients. / Muffly, Lori S.; Kocherginsky, Masha; Stock, Wendy; Chu, Quynh; Bishop, Michael R.; Godley, Lucy A.; Kline, Justin; Liu, Hongtao; Odenike, Olatoyosi M.; Larson, Richard A.; van Besien, Koen; Artz, Andrew S.

In: Haematologica, Vol. 99, No. 8, 01.08.2014, p. 1373-1379.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients

AU - Muffly, Lori S.

AU - Kocherginsky, Masha

AU - Stock, Wendy

AU - Chu, Quynh

AU - Bishop, Michael R.

AU - Godley, Lucy A.

AU - Kline, Justin

AU - Liu, Hongtao

AU - Odenike, Olatoyosi M.

AU - Larson, Richard A.

AU - van Besien, Koen

AU - Artz, Andrew S.

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Allogeneic hematopoietic cell transplantation is increasingly utilized in older adults. This study prospectively evaluated the prognostic utility of geriatric assessment domains prior to allogeneic transplantation in recipients aged 50 years and over. Geriatric assessment was performed prior to transplant, and included validated measures across domains of function and disability, comorbidity, frailty, mental health, nutritional status, and systemic inflammation. A total of 203 patients completed geriatric assessment and underwent transplant. Median age was 58 years (range 50-73). After adjusting for established prognostic factors, limitations in instrumental activities of daily living (HR 2.38, 95%CI: 1.59-3.56; P<0.001), slow walk speed (HR 1.80, 95%CI: 1.14-2.83; P=0.01), high comorbidity by hematopoietic cell transplantation-specific comorbidity index (HR 1.56, 95%CI: 1.07-2.28; P=0.02), low mental health by short-form-36 mental component summary (HR 1.67, 95%CI: 1.13-2.48; P=0.01), and elevated serum C-reactive protein (HR 2.51, 95%CI: 1.54-4.09; P<0.001) were significantly associated with inferior overall survival. These associations were more pronounced in the cohort 60 years and over. Geriatric assessment measures confer independent prognostic utility in older allogeneic transplant recipients. Implementation of geriatric assessment prior to allogeneic transplantation may aid appropriate selection of older adults.

AB - Allogeneic hematopoietic cell transplantation is increasingly utilized in older adults. This study prospectively evaluated the prognostic utility of geriatric assessment domains prior to allogeneic transplantation in recipients aged 50 years and over. Geriatric assessment was performed prior to transplant, and included validated measures across domains of function and disability, comorbidity, frailty, mental health, nutritional status, and systemic inflammation. A total of 203 patients completed geriatric assessment and underwent transplant. Median age was 58 years (range 50-73). After adjusting for established prognostic factors, limitations in instrumental activities of daily living (HR 2.38, 95%CI: 1.59-3.56; P<0.001), slow walk speed (HR 1.80, 95%CI: 1.14-2.83; P=0.01), high comorbidity by hematopoietic cell transplantation-specific comorbidity index (HR 1.56, 95%CI: 1.07-2.28; P=0.02), low mental health by short-form-36 mental component summary (HR 1.67, 95%CI: 1.13-2.48; P=0.01), and elevated serum C-reactive protein (HR 2.51, 95%CI: 1.54-4.09; P<0.001) were significantly associated with inferior overall survival. These associations were more pronounced in the cohort 60 years and over. Geriatric assessment measures confer independent prognostic utility in older allogeneic transplant recipients. Implementation of geriatric assessment prior to allogeneic transplantation may aid appropriate selection of older adults.

UR - http://www.scopus.com/inward/record.url?scp=84905160745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905160745&partnerID=8YFLogxK

U2 - 10.3324/haematol.2014.103655

DO - 10.3324/haematol.2014.103655

M3 - Article

VL - 99

SP - 1373

EP - 1379

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 8

ER -