Germ Cell Tumors of the Ovary

Daniela E. Matei*, Jeanne M. Schilder, Helen Michael

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ovarian germ cell tumors (OGCT) are rare malignancies that occur in young women. Histologically they are classified as dysgerminoma, yolk sac tumor, embryonal carcinoma, polyembryoma, nongestational choriocarcinoma, and teratomas and mixed cell tumors. Because of the development of cisplatin-based chemotherapy, virtually all patients with early stage, completely resected OGCTs will survive after careful surgical staging and three courses of adjuvant BEP. Furthermore, 70-80% of patients with incompletely resected or advanced tumors will be long-term survivors. Acute toxicity of treatment is relatively modest. Late consequences of chemotherapy are limited. Efforts should concentrate on fertility preservation for patients who desire subsequent pregnancies.

Original languageEnglish (US)
Title of host publicationTextbook of Uncommon Cancer, Third Edition
PublisherJohn Wiley & Sons, Ltd
Pages467-476
Number of pages10
ISBN (Print)0470012021, 9780470012024
DOIs
StatePublished - Jul 11 2006

Keywords

  • Chemotherapy
  • Germ cell tumor
  • Ovarian cancer

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Matei, D. E., Schilder, J. M., & Michael, H. (2006). Germ Cell Tumors of the Ovary. In Textbook of Uncommon Cancer, Third Edition (pp. 467-476). John Wiley & Sons, Ltd. https://doi.org/10.1002/0470030542.ch42