Germ Cell Tumors of the Ovary

Daniela E. Matei*, Jeanne M. Schilder, Helen Michael

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Ovarian germ cell tumors are rare malignancies that occur in young women. Histologically they are classified as dysgerminoma, yolk sac tumor, embryonal carcinoma, polyembryoma, nongestational choriocarcinoma, and teratomas and mixed cell tumors. Due to the development of cisplatin-based chemotherapy, virtually all patients with early-stage, completely resected ovarian germ cell tumors will survive after careful surgical staging and three courses of adjuvant bleomycin, etoposide, and cisplatin. Furthermore, 70-80% of patients with incompletely resected or advanced tumors will be long-term survivors. Acute toxicity of treatment is relatively modest. Late consequences of chemotherapy are limited. Efforts should concentrate on fertility preservation for patients who desire subsequent pregnancies.

Original languageEnglish (US)
Title of host publicationTextbook of Uncommon Cancer
PublisherJohn Wiley and Sons
Pages519-530
Number of pages12
ISBN (Print)9781118083734
DOIs
StatePublished - Sep 20 2012

Keywords

  • Chemotherapy
  • Dysgerminoma
  • Malignant tumors
  • Nondysgerminomatous ovarian germ cell tumors
  • OGCT
  • Radiation therapy
  • Residual/recurrent disease
  • Small cell carcinoma
  • Yolk sac tumor

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Matei, D. E., Schilder, J. M., & Michael, H. (2012). Germ Cell Tumors of the Ovary. In Textbook of Uncommon Cancer (pp. 519-530). John Wiley and Sons. https://doi.org/10.1002/9781118464557.ch37