Gestational and postpartum weight trajectories among women with and without asthma

Danielle R. Stevens, William A Grobman, Rajesh Kumar, Leah M. Lipsky, Stefanie N. Hinkle, Zhen Chen, Andrew Williams, Matthew C.H. Rohn, Jenna Kanner, Seth Sherman, Pauline Mendola*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Asthma leads to increased weight gain in nonpregnant populations, but studies have not examined this association within the context of pregnancy. The association between asthma and perinatal weight trajectories was examined in the Breathe-Wellbeing, Environment, Lifestyle, and Lung Function Study (2015-2019). Multilevel linear spline models were adjusted for age, race/ethnicity, income, marital status, education, cigarette smoking, parity, study site, and prepregnancy body mass index were used to examine differences in perinatal weight trajectories between women with (n = 299) and without (n = 101) asthma. Secondary analyses were conducted to assess whether associations differed by asthma phenotypes. At 40 weeks' gestation, women with asthma gained 16.2 kg (95% confidence interval (CI): 14.6, 17.7) and women without asthma gained 13.1 kg (95% CI: 10.9, 15.4). At 3 months postpartum, women with asthma retained 10.4 kg (95% CI: 8.9, 11.9) and women without asthma retained 8.0 kg (95% CI: 5.9, 10.2). Among women with asthma, exercise-induced asthma and step 3 asthma medications were associated with excess gestational weight gain. These study findings suggest women with asthma gain and retain more weight during pregnancy and postpartum than do women without asthma.

Original languageEnglish (US)
Pages (from-to)744-754
Number of pages11
JournalAmerican journal of epidemiology
Issue number5
StatePublished - 2021


  • Asthma
  • Body mass index
  • Exercise-induced asthma
  • Gestational weight gain
  • Obesity
  • Postpartum period
  • Postpartum weight retention
  • Pregnancy

ASJC Scopus subject areas

  • Epidemiology


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