TY - JOUR
T1 - Gestational and postpartum weight trajectories among women with and without asthma
AU - Stevens, Danielle R.
AU - Grobman, William A
AU - Kumar, Rajesh
AU - Lipsky, Leah M.
AU - Hinkle, Stefanie N.
AU - Chen, Zhen
AU - Williams, Andrew
AU - Rohn, Matthew C.H.
AU - Kanner, Jenna
AU - Sherman, Seth
AU - Mendola, Pauline
N1 - Funding Information:
Author affiliations: Author affiliations: Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States (Danielle R. Stevens, Stefanie N. Hinkle, Matthew C. H. Rohn, Jenna Kanner, Pauline Mendola); Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States (William Grobman); Social and Behavioral Sciences Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States (Leah M. Lipsky); Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States (Zhen Chen); School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, United States(Andrew Williams); and The Emmes Company, Rockville, Maryland, United States (Seth Sherman). Dr. Mendola is now at the School of Public Health and Health Professions, University ad Buffalo, Buffalo, New York, United States. This work was supported by the National Institutes of Health’s Intramural Research Program at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (clinical site contracts HHSN275201300013C to Northwestern University; HHSN275201300014C to the University of Alabama at Birmingham; and HHSN275201300026I, HHSN27500001, and HHSN275000017 to the Emmes Company for the Data Coordinating Center). Funding sources were not involved in the study design, collection, analysis, and interpretation of the data or in the writing and decision to submit the manuscript for publication. Conflict of interest: none declared.
Publisher Copyright:
© 2021 The Author(s).
PY - 2021
Y1 - 2021
N2 - Asthma leads to increased weight gain in nonpregnant populations, but studies have not examined this association within the context of pregnancy. The association between asthma and perinatal weight trajectories was examined in the Breathe-Wellbeing, Environment, Lifestyle, and Lung Function Study (2015-2019). Multilevel linear spline models were adjusted for age, race/ethnicity, income, marital status, education, cigarette smoking, parity, study site, and prepregnancy body mass index were used to examine differences in perinatal weight trajectories between women with (n = 299) and without (n = 101) asthma. Secondary analyses were conducted to assess whether associations differed by asthma phenotypes. At 40 weeks' gestation, women with asthma gained 16.2 kg (95% confidence interval (CI): 14.6, 17.7) and women without asthma gained 13.1 kg (95% CI: 10.9, 15.4). At 3 months postpartum, women with asthma retained 10.4 kg (95% CI: 8.9, 11.9) and women without asthma retained 8.0 kg (95% CI: 5.9, 10.2). Among women with asthma, exercise-induced asthma and step 3 asthma medications were associated with excess gestational weight gain. These study findings suggest women with asthma gain and retain more weight during pregnancy and postpartum than do women without asthma.
AB - Asthma leads to increased weight gain in nonpregnant populations, but studies have not examined this association within the context of pregnancy. The association between asthma and perinatal weight trajectories was examined in the Breathe-Wellbeing, Environment, Lifestyle, and Lung Function Study (2015-2019). Multilevel linear spline models were adjusted for age, race/ethnicity, income, marital status, education, cigarette smoking, parity, study site, and prepregnancy body mass index were used to examine differences in perinatal weight trajectories between women with (n = 299) and without (n = 101) asthma. Secondary analyses were conducted to assess whether associations differed by asthma phenotypes. At 40 weeks' gestation, women with asthma gained 16.2 kg (95% confidence interval (CI): 14.6, 17.7) and women without asthma gained 13.1 kg (95% CI: 10.9, 15.4). At 3 months postpartum, women with asthma retained 10.4 kg (95% CI: 8.9, 11.9) and women without asthma retained 8.0 kg (95% CI: 5.9, 10.2). Among women with asthma, exercise-induced asthma and step 3 asthma medications were associated with excess gestational weight gain. These study findings suggest women with asthma gain and retain more weight during pregnancy and postpartum than do women without asthma.
KW - Asthma
KW - Body mass index
KW - Exercise-induced asthma
KW - Gestational weight gain
KW - Obesity
KW - Postpartum period
KW - Postpartum weight retention
KW - Pregnancy
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U2 - 10.1093/aje/kwaa248
DO - 10.1093/aje/kwaa248
M3 - Article
C2 - 33169142
AN - SCOPUS:85105643088
SN - 0002-9262
VL - 190
SP - 744
EP - 754
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 5
ER -
