Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder

Heejoo Jo, Sandrah P. Eckel, Jiu Chiuan Chen, Myles Cockburn, Mayra P. Martinez, Ting Chow, Frederick W. Lurmann, William E. Funk, Anny H. Xiang, Rob McConnell*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: Ambient air pollution and maternal diabetes may affect common biological pathways underlying adverse neurodevelopmental effects. However, joint effects of maternal diabetes and air pollution on autism spectrum disorder (ASD) have not been studied. Objective: We evaluated whether prenatal and early-life air pollution exposure interacts with maternal diabetes status to affect ASD risk. Methods: This retrospective cohort study included 246,420 singleton children born in Kaiser Permanente Southern California hospitals in 1999–2009. Children were followed from birth until age 5, during which 2471 ASD cases were diagnosed. Ozone (O3), particulate matter < 2.5 μm (PM2.5) and <10 μm in aerodynamic diameter, and nitrogen dioxide measured at regulatory air monitoring stations were interpolated to estimate exposures during preconception and each pregnancy trimester, and first year of life at each child's birth address. Hazard ratios (HRs) for ASD were estimated adjusting for birth year, KPSC service areas, and relevant maternal and child characteristics. For each exposure window, interactions were tested between pollutants and a 4-category maternal diabetes variable (none, GDM ≥ 24 and <24 weeks' gestation, and pre-existing type 2 diabetes). For an exposure window with statistically significant global interaction between pollutant and diabetes (p < 0.05), pollutant-associated HRs were estimated separately for each category of maternal diabetes. Results: There were associations of ASD with preconception, first and third trimesters, and first year of life PM2.5, but not with other pollutants. There were, however, interactions of maternal diabetes with first trimester and first year of life O3. Increased ASD risk was associated with first trimester O3 among mothers with GDM < 24 weeks' gestation [adjusted HR 1.50 per 15.7 ppb O3 (95% CI: 1.08–2.09)]. No O3 associations with ASD were observed in other categories of maternal diabetes. Conclusions: GDM onset early in pregnancy may increase children's susceptibility to prenatal O3-associated ASD risk. These novel findings merit further investigation.

Original languageEnglish (US)
Article number105110
JournalEnvironment International
Volume133
DOIs
StatePublished - Dec 2019

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pollution exposure
diabetes
atmospheric pollution
pregnancy
pollutant
hazard
nitrogen dioxide
ambient air
aerodynamics
particulate matter
ozone

Keywords

  • Air pollution
  • Autism
  • Gestational diabetes mellitus
  • Pregnancy

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Jo, H., Eckel, S. P., Chen, J. C., Cockburn, M., Martinez, M. P., Chow, T., ... McConnell, R. (2019). Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder. Environment International, 133, [105110]. https://doi.org/10.1016/j.envint.2019.105110
Jo, Heejoo ; Eckel, Sandrah P. ; Chen, Jiu Chiuan ; Cockburn, Myles ; Martinez, Mayra P. ; Chow, Ting ; Lurmann, Frederick W. ; Funk, William E. ; Xiang, Anny H. ; McConnell, Rob. / Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder. In: Environment International. 2019 ; Vol. 133.
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abstract = "Background: Ambient air pollution and maternal diabetes may affect common biological pathways underlying adverse neurodevelopmental effects. However, joint effects of maternal diabetes and air pollution on autism spectrum disorder (ASD) have not been studied. Objective: We evaluated whether prenatal and early-life air pollution exposure interacts with maternal diabetes status to affect ASD risk. Methods: This retrospective cohort study included 246,420 singleton children born in Kaiser Permanente Southern California hospitals in 1999–2009. Children were followed from birth until age 5, during which 2471 ASD cases were diagnosed. Ozone (O3), particulate matter < 2.5 μm (PM2.5) and <10 μm in aerodynamic diameter, and nitrogen dioxide measured at regulatory air monitoring stations were interpolated to estimate exposures during preconception and each pregnancy trimester, and first year of life at each child's birth address. Hazard ratios (HRs) for ASD were estimated adjusting for birth year, KPSC service areas, and relevant maternal and child characteristics. For each exposure window, interactions were tested between pollutants and a 4-category maternal diabetes variable (none, GDM ≥ 24 and <24 weeks' gestation, and pre-existing type 2 diabetes). For an exposure window with statistically significant global interaction between pollutant and diabetes (p < 0.05), pollutant-associated HRs were estimated separately for each category of maternal diabetes. Results: There were associations of ASD with preconception, first and third trimesters, and first year of life PM2.5, but not with other pollutants. There were, however, interactions of maternal diabetes with first trimester and first year of life O3. Increased ASD risk was associated with first trimester O3 among mothers with GDM < 24 weeks' gestation [adjusted HR 1.50 per 15.7 ppb O3 (95{\%} CI: 1.08–2.09)]. No O3 associations with ASD were observed in other categories of maternal diabetes. Conclusions: GDM onset early in pregnancy may increase children's susceptibility to prenatal O3-associated ASD risk. These novel findings merit further investigation.",
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author = "Heejoo Jo and Eckel, {Sandrah P.} and Chen, {Jiu Chiuan} and Myles Cockburn and Martinez, {Mayra P.} and Ting Chow and Lurmann, {Frederick W.} and Funk, {William E.} and Xiang, {Anny H.} and Rob McConnell",
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Jo, H, Eckel, SP, Chen, JC, Cockburn, M, Martinez, MP, Chow, T, Lurmann, FW, Funk, WE, Xiang, AH & McConnell, R 2019, 'Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder', Environment International, vol. 133, 105110. https://doi.org/10.1016/j.envint.2019.105110

Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder. / Jo, Heejoo; Eckel, Sandrah P.; Chen, Jiu Chiuan; Cockburn, Myles; Martinez, Mayra P.; Chow, Ting; Lurmann, Frederick W.; Funk, William E.; Xiang, Anny H.; McConnell, Rob.

In: Environment International, Vol. 133, 105110, 12.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gestational diabetes mellitus, prenatal air pollution exposure, and autism spectrum disorder

AU - Jo, Heejoo

AU - Eckel, Sandrah P.

AU - Chen, Jiu Chiuan

AU - Cockburn, Myles

AU - Martinez, Mayra P.

AU - Chow, Ting

AU - Lurmann, Frederick W.

AU - Funk, William E.

AU - Xiang, Anny H.

AU - McConnell, Rob

PY - 2019/12

Y1 - 2019/12

N2 - Background: Ambient air pollution and maternal diabetes may affect common biological pathways underlying adverse neurodevelopmental effects. However, joint effects of maternal diabetes and air pollution on autism spectrum disorder (ASD) have not been studied. Objective: We evaluated whether prenatal and early-life air pollution exposure interacts with maternal diabetes status to affect ASD risk. Methods: This retrospective cohort study included 246,420 singleton children born in Kaiser Permanente Southern California hospitals in 1999–2009. Children were followed from birth until age 5, during which 2471 ASD cases were diagnosed. Ozone (O3), particulate matter < 2.5 μm (PM2.5) and <10 μm in aerodynamic diameter, and nitrogen dioxide measured at regulatory air monitoring stations were interpolated to estimate exposures during preconception and each pregnancy trimester, and first year of life at each child's birth address. Hazard ratios (HRs) for ASD were estimated adjusting for birth year, KPSC service areas, and relevant maternal and child characteristics. For each exposure window, interactions were tested between pollutants and a 4-category maternal diabetes variable (none, GDM ≥ 24 and <24 weeks' gestation, and pre-existing type 2 diabetes). For an exposure window with statistically significant global interaction between pollutant and diabetes (p < 0.05), pollutant-associated HRs were estimated separately for each category of maternal diabetes. Results: There were associations of ASD with preconception, first and third trimesters, and first year of life PM2.5, but not with other pollutants. There were, however, interactions of maternal diabetes with first trimester and first year of life O3. Increased ASD risk was associated with first trimester O3 among mothers with GDM < 24 weeks' gestation [adjusted HR 1.50 per 15.7 ppb O3 (95% CI: 1.08–2.09)]. No O3 associations with ASD were observed in other categories of maternal diabetes. Conclusions: GDM onset early in pregnancy may increase children's susceptibility to prenatal O3-associated ASD risk. These novel findings merit further investigation.

AB - Background: Ambient air pollution and maternal diabetes may affect common biological pathways underlying adverse neurodevelopmental effects. However, joint effects of maternal diabetes and air pollution on autism spectrum disorder (ASD) have not been studied. Objective: We evaluated whether prenatal and early-life air pollution exposure interacts with maternal diabetes status to affect ASD risk. Methods: This retrospective cohort study included 246,420 singleton children born in Kaiser Permanente Southern California hospitals in 1999–2009. Children were followed from birth until age 5, during which 2471 ASD cases were diagnosed. Ozone (O3), particulate matter < 2.5 μm (PM2.5) and <10 μm in aerodynamic diameter, and nitrogen dioxide measured at regulatory air monitoring stations were interpolated to estimate exposures during preconception and each pregnancy trimester, and first year of life at each child's birth address. Hazard ratios (HRs) for ASD were estimated adjusting for birth year, KPSC service areas, and relevant maternal and child characteristics. For each exposure window, interactions were tested between pollutants and a 4-category maternal diabetes variable (none, GDM ≥ 24 and <24 weeks' gestation, and pre-existing type 2 diabetes). For an exposure window with statistically significant global interaction between pollutant and diabetes (p < 0.05), pollutant-associated HRs were estimated separately for each category of maternal diabetes. Results: There were associations of ASD with preconception, first and third trimesters, and first year of life PM2.5, but not with other pollutants. There were, however, interactions of maternal diabetes with first trimester and first year of life O3. Increased ASD risk was associated with first trimester O3 among mothers with GDM < 24 weeks' gestation [adjusted HR 1.50 per 15.7 ppb O3 (95% CI: 1.08–2.09)]. No O3 associations with ASD were observed in other categories of maternal diabetes. Conclusions: GDM onset early in pregnancy may increase children's susceptibility to prenatal O3-associated ASD risk. These novel findings merit further investigation.

KW - Air pollution

KW - Autism

KW - Gestational diabetes mellitus

KW - Pregnancy

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