Gestational trophoblastic disease II: Classification and management of gestational trophoblastic neoplasia

John Robert Lurain III

Research output: Contribution to journalReview articlepeer-review

245 Scopus citations

Abstract

Gestational trophoblastic neoplasia (GTN) includes invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. The overall cure rate in treating these tumors is currently >90%. Thorough evaluation and staging allow selection of appropriate therapy that maximizes chances for cure while minimizing toxicity. Nonmetastatic (stage I) and low-risk metastatic (stages II and III, score <7) GTN can be treated with single-agent chemotherapy resulting in a survival rate approaching 100%. High-risk GTN (stages II-IV, score <7) requires initial multiagent chemotherapy with or without adjuvant radiation and surgery to achieve a survival rate of 80-90%.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalAmerican journal of obstetrics and gynecology
Volume204
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • chemotherapy
  • choriocarcinoma
  • gestational trophoblastic disease
  • gestational trophoblastic neoplasia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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