Getting Leukocytes to the Site of Inflammation

Research output: Contribution to journalReview articlepeer-review

140 Scopus citations

Abstract

There is no "response" in either the innate or adaptive immune response unless leukocytes cross blood vessels. They do this through the process of diapedesis, in which the leukocyte moves in ameboid fashion through tightly apposed endothelial borders (paracellular transmigration) and in some cases through the endothelial cell itself (transcellular migration). This review summarizes the steps leading up to diapedesis, then focuses on the molecules and mechanisms responsible for transendothelial migration. Surprisingly, many of the same molecules and mechanisms that regulate paracellular migration also control transcellular migration, including a major role for membrane from the recently described lateral border recycling compartment. A hypothesis that integrates the various known mechanisms of transmigration is proposed.

Original languageEnglish (US)
Pages (from-to)7-22
Number of pages16
JournalVeterinary Pathology
Volume50
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • cell junctions
  • diapedesis
  • endothelial cell
  • inflammation
  • lateral border recycling compartment
  • leukocyte
  • platelet/endothelial cell adhesion molecule

ASJC Scopus subject areas

  • veterinary(all)

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