Getting pumped: Membrane efflux transporters for enhanced biomolecule production

Sergey Boyarskiy, Danielle Tullman-Ercek*

*Corresponding author for this work

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Small molecule production in microbial hosts is limited by the accumulation of the product inside the cell. Efflux transporters show promise as a solution to removal of the often-toxic products. Recent advances in transporter identification through expression profiling, heterologous expression, and knockout studies have identified transporters capable of secreting compounds of biotechnological interest. In addition, engineering of well-studied transporters has shown that substrate specificity in these transporters is malleable. Future work in identification, engineering, and expression of small molecule exporters can be instrumental in expanding the biocatalysis portfolio.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalCurrent Opinion in Chemical Biology
Volume28
DOIs
StatePublished - Oct 1 2015

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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