Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy

Timothy B Lautz, M. J. Finegold, Anthony C Chin, Riccardo A Superina*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

An association between oxcarbazepine therapy and hepatic adenoma (HA) has been documented in animal models but not observed in humans. The authors report a case of a 16-year-old girl on oxcarbazepine therapy for seizure disorder who presented with a giant HA. Pathology of the HA was notable for marked periductal fibrosis and glycoprotein inclusions in the nontumor liver. The patient was not on oral contraceptives and has no other known risk factors for HA.

Original languageEnglish (US)
Pages (from-to)751-754
Number of pages4
JournalJournal of Pediatric Surgery
Volume43
Issue number4
DOIs
StatePublished - Apr 1 2008

Fingerprint

Adenoma
Liver
Therapeutics
Oral Contraceptives
Epilepsy
Glycoproteins
Fibrosis
Animal Models
oxcarbazepine
Pathology

Keywords

  • Antiepileptic medication
  • Seizure
  • Surgery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

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title = "Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy",
abstract = "An association between oxcarbazepine therapy and hepatic adenoma (HA) has been documented in animal models but not observed in humans. The authors report a case of a 16-year-old girl on oxcarbazepine therapy for seizure disorder who presented with a giant HA. Pathology of the HA was notable for marked periductal fibrosis and glycoprotein inclusions in the nontumor liver. The patient was not on oral contraceptives and has no other known risk factors for HA.",
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Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy. / Lautz, Timothy B; Finegold, M. J.; Chin, Anthony C; Superina, Riccardo A.

In: Journal of Pediatric Surgery, Vol. 43, No. 4, 01.04.2008, p. 751-754.

Research output: Contribution to journalArticle

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