Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy

T. B. Lautz; M. J. Finegold; A. C. Chin; R. A. Superina

doi:10.1016/j.jpedsurg.2007.11.036

Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy

T. B. Lautz, M. J. Finegold, A. C. Chin, R. A. Superina^*

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

An association between oxcarbazepine therapy and hepatic adenoma (HA) has been documented in animal models but not observed in humans. The authors report a case of a 16-year-old girl on oxcarbazepine therapy for seizure disorder who presented with a giant HA. Pathology of the HA was notable for marked periductal fibrosis and glycoprotein inclusions in the nontumor liver. The patient was not on oral contraceptives and has no other known risk factors for HA.

Original language	English (US)
Pages (from-to)	751-754
Number of pages	4
Journal	Journal of pediatric surgery
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/j.jpedsurg.2007.11.036
State	Published - Apr 2008

Keywords

Antiepileptic medication
Seizure
Surgery

ASJC Scopus subject areas

Surgery
Pediatrics, Perinatology, and Child Health

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10.1016/j.jpedsurg.2007.11.036

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abstract = "An association between oxcarbazepine therapy and hepatic adenoma (HA) has been documented in animal models but not observed in humans. The authors report a case of a 16-year-old girl on oxcarbazepine therapy for seizure disorder who presented with a giant HA. Pathology of the HA was notable for marked periductal fibrosis and glycoprotein inclusions in the nontumor liver. The patient was not on oral contraceptives and has no other known risk factors for HA.",

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AU - Chin, A. C.

AU - Superina, R. A.

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N2 - An association between oxcarbazepine therapy and hepatic adenoma (HA) has been documented in animal models but not observed in humans. The authors report a case of a 16-year-old girl on oxcarbazepine therapy for seizure disorder who presented with a giant HA. Pathology of the HA was notable for marked periductal fibrosis and glycoprotein inclusions in the nontumor liver. The patient was not on oral contraceptives and has no other known risk factors for HA.

AB - An association between oxcarbazepine therapy and hepatic adenoma (HA) has been documented in animal models but not observed in humans. The authors report a case of a 16-year-old girl on oxcarbazepine therapy for seizure disorder who presented with a giant HA. Pathology of the HA was notable for marked periductal fibrosis and glycoprotein inclusions in the nontumor liver. The patient was not on oral contraceptives and has no other known risk factors for HA.

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KW - Surgery

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Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy

Abstract

Keywords

ASJC Scopus subject areas

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