Ginsenoside-Rg1 down-regulates glucocorticoid receptor and displays synergistic effects with cAMP

Eunah Chung, Kwang Youl Lee, Youngjoo Lee, Yong Hee Lee, Seung Ki Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Ginsenoside-Rg1 (G-Rg1) from the roots of Panax ginseng C. A. Meyer has been shown to bind to the glucocorticoid receptor (GR). To further explore the effect of G-Rg1 binding to GR, a luciferase reporter gene containing two copies of a glucocorticoid response element was constructed and transiently transfected into FTO2B rat hepatoma cells. A dose-dependent induction of the reporter gene was observed in response to G-Rg1, and the inductive effect was blocked by treatment with the antiglucocorticoid RU486. In addition, both G-Rg1 and dexamethasone (Dex)-induced transcription was synergistically enhanced by the treatment of dibutyryl cAMP (Bt2-cAMP). G- Rg1 treatment also led to the down-regulation of intracellular GR content, which was similar to the effect of Dex. By showing that G-Rg1 down-regulates GR and induces GR-mediated transcription synergistically with cAMP, we conclude that G-Rg1 is a functional GR ligand in FTO2B cells.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
Issue number7-8
StatePublished - Jul 1998


  • CAMP
  • Ginseng
  • Ginsenoside-Rg
  • Glucocorticoid receptor
  • Glucocorticoid receptor down-regulation

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry
  • Clinical Biochemistry
  • Pharmacology
  • Organic Chemistry


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