TY - JOUR
T1 - Glaucoma and Cornea Surgery Outcomes in Peters Anomaly
AU - Dolezal, Kara A.
AU - Besirli, Cagri G.
AU - Mian, Shahzad I.
AU - Sugar, Alan
AU - Moroi, Sayoko E.
AU - Bohnsack, Brenda L.
N1 - Funding Information:
All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. Funding/Support: Dr Bohnsack was supported in part by Research to Prevent Blindness (New York, New York). The other authors indicate no financial support or financial conflict of interest. All authors attest that they meet the current ICMJE criteria for authorship.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/12
Y1 - 2019/12
N2 - Purpose: To conduct a qualitative description of corneal and glaucoma outcomes in Peters anomaly. Design: Retrospective case series. Methods: Children with Peters anomaly who presented between 1982–2017 were included. Visual acuity, intraocular pressure (IOP), survival of corneal grafts, and success of glaucoma surgery (defined as IOP of 5–20 mm Hg and no additional IOP-lowering surgery or visually devastating complications) were analyzed. Results: Fifty-eight eyes of 37 patients (19 males) with Peters anomaly presented at 0.7 ± 1.5 years of age and had a follow-up of 10.2 ± 10.8 years. Twenty-three eyes underwent penetrating keratoplasty (PKP) with an average of 2.0 ± 1.3 grafts per eye. PKP survival at 1 year was 60% (95% confidence interval 41–75%) but decreased at 10 years to 34% (95% confidence interval 18–51%). Thirty-four eyes were diagnosed with glaucoma at 2.8 ± 6.4 years of age. Twenty eyes required glaucoma surgery, and the average number of IOP-lowering surgeries was 2.9 ± 2.0 per eye. Glaucoma drainage devices (15 eyes) had a 53% success rate. Laser cycloablation (9 eyes, transcleral or endoscopic) had a success rate of 67% with 2.0 ± 1.0 treatments per eye. Trabeculectomy with mitomycin C (8 eyes) and trabeculotomy (8 eyes) had 25% and 0% success rates, respectively. Fifteen eyes that underwent glaucoma surgery obtained IOP control, and GDD with or without cycloablation accounted for 80% of the successes. Eyes that underwent PKP did not show increased rates of glaucoma, higher IOP, or a greater necessity for IOP-lowering surgery. Conclusions: In Peters anomaly, PKP shows poor long-term success. In addition, >50% of eyes with Peters anomaly have secondary glaucoma that often requires multiple surgeries.
AB - Purpose: To conduct a qualitative description of corneal and glaucoma outcomes in Peters anomaly. Design: Retrospective case series. Methods: Children with Peters anomaly who presented between 1982–2017 were included. Visual acuity, intraocular pressure (IOP), survival of corneal grafts, and success of glaucoma surgery (defined as IOP of 5–20 mm Hg and no additional IOP-lowering surgery or visually devastating complications) were analyzed. Results: Fifty-eight eyes of 37 patients (19 males) with Peters anomaly presented at 0.7 ± 1.5 years of age and had a follow-up of 10.2 ± 10.8 years. Twenty-three eyes underwent penetrating keratoplasty (PKP) with an average of 2.0 ± 1.3 grafts per eye. PKP survival at 1 year was 60% (95% confidence interval 41–75%) but decreased at 10 years to 34% (95% confidence interval 18–51%). Thirty-four eyes were diagnosed with glaucoma at 2.8 ± 6.4 years of age. Twenty eyes required glaucoma surgery, and the average number of IOP-lowering surgeries was 2.9 ± 2.0 per eye. Glaucoma drainage devices (15 eyes) had a 53% success rate. Laser cycloablation (9 eyes, transcleral or endoscopic) had a success rate of 67% with 2.0 ± 1.0 treatments per eye. Trabeculectomy with mitomycin C (8 eyes) and trabeculotomy (8 eyes) had 25% and 0% success rates, respectively. Fifteen eyes that underwent glaucoma surgery obtained IOP control, and GDD with or without cycloablation accounted for 80% of the successes. Eyes that underwent PKP did not show increased rates of glaucoma, higher IOP, or a greater necessity for IOP-lowering surgery. Conclusions: In Peters anomaly, PKP shows poor long-term success. In addition, >50% of eyes with Peters anomaly have secondary glaucoma that often requires multiple surgeries.
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U2 - 10.1016/j.ajo.2019.08.012
DO - 10.1016/j.ajo.2019.08.012
M3 - Article
C2 - 31470000
AN - SCOPUS:85072701552
SN - 0002-9394
VL - 208
SP - 367
EP - 375
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
ER -