Glial cell line-derived neurotrophic factor (GDNF) as a defensive molecule for neurodegenerative disease: A tribute to the studies of Antonia Vernadakis on neuronal-glial interactions

Martha C. Bohn; Dorothy A. Kozlowski; Bronwen Connor

doi:10.1016/S0736-5748(00)00036-8

Glial cell line-derived neurotrophic factor (GDNF) as a defensive molecule for neurodegenerative disease: A tribute to the studies of Antonia Vernadakis on neuronal-glial interactions

Martha C. Bohn^*, Dorothy A. Kozlowski, Bronwen Connor

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Short survey › peer-review

17 Scopus citations

Abstract

Research stemming from interests in neuronal-glial interactions has led to the identification of a number of novel trophic factors, such as the dopaminergic neurotrophic factor glial cell line-derived neurotrophic factor (GDNF). Delivery of the GDNF gene to rat models of Parkinson's disease suggests a potential clinical use of GDNF gene therapy for humans with this disease. This review article briefly summarizes the history of GDNF and the effects of GDNF gene delivery prior to or after a lesion of the rat nigrostriatal system. Copyright (C) 2000 ISDN.

Original language	English (US)
Pages (from-to)	679-684
Number of pages	6
Journal	International Journal of Developmental Neuroscience
Volume	18
Issue number	7
DOIs	https://doi.org/10.1016/S0736-5748(00)00036-8
State	Published - Nov 2000

Keywords

Adenovirus
Amyotrophic lateral sclerosis
Dopaminergic neurons
Gene therapy
Motoneurons
Parkinson's disease
Tyrosine hydroxylase

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/S0736-5748(00)00036-8

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title = "Glial cell line-derived neurotrophic factor (GDNF) as a defensive molecule for neurodegenerative disease: A tribute to the studies of Antonia Vernadakis on neuronal-glial interactions",

abstract = "Research stemming from interests in neuronal-glial interactions has led to the identification of a number of novel trophic factors, such as the dopaminergic neurotrophic factor glial cell line-derived neurotrophic factor (GDNF). Delivery of the GDNF gene to rat models of Parkinson's disease suggests a potential clinical use of GDNF gene therapy for humans with this disease. This review article briefly summarizes the history of GDNF and the effects of GDNF gene delivery prior to or after a lesion of the rat nigrostriatal system. Copyright (C) 2000 ISDN.",

keywords = "Adenovirus, Amyotrophic lateral sclerosis, Dopaminergic neurons, Gene therapy, Motoneurons, Parkinson's disease, Tyrosine hydroxylase",

author = "Bohn, {Martha C.} and Kozlowski, {Dorothy A.} and Bronwen Connor",

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Glial cell line-derived neurotrophic factor (GDNF) as a defensive molecule for neurodegenerative disease: A tribute to the studies of Antonia Vernadakis on neuronal-glial interactions. / Bohn, Martha C.; Kozlowski, Dorothy A.; Connor, Bronwen.
In: International Journal of Developmental Neuroscience, Vol. 18, No. 7, 11.2000, p. 679-684.

Research output: Contribution to journal › Short survey › peer-review

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AU - Kozlowski, Dorothy A.

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KW - Amyotrophic lateral sclerosis

KW - Dopaminergic neurons

KW - Gene therapy

KW - Motoneurons

KW - Parkinson's disease

KW - Tyrosine hydroxylase

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Glial cell line-derived neurotrophic factor (GDNF) as a defensive molecule for neurodegenerative disease: A tribute to the studies of Antonia Vernadakis on neuronal-glial interactions

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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