Glial cell line-derived neurotrophic factor (GDNF) as a defensive molecule for neurodegenerative disease: A tribute to the studies of Antonia Vernadakis on neuronal-glial interactions

Martha C. Bohn*, Dorothy A. Kozlowski, Bronwen Connor

*Corresponding author for this work

Research output: Contribution to journalShort survey

16 Scopus citations

Abstract

Research stemming from interests in neuronal-glial interactions has led to the identification of a number of novel trophic factors, such as the dopaminergic neurotrophic factor glial cell line-derived neurotrophic factor (GDNF). Delivery of the GDNF gene to rat models of Parkinson's disease suggests a potential clinical use of GDNF gene therapy for humans with this disease. This review article briefly summarizes the history of GDNF and the effects of GDNF gene delivery prior to or after a lesion of the rat nigrostriatal system. Copyright (C) 2000 ISDN.

Original languageEnglish (US)
Pages (from-to)679-684
Number of pages6
JournalInternational Journal of Developmental Neuroscience
Volume18
Issue number7
DOIs
StatePublished - Nov 2000

Keywords

  • Adenovirus
  • Amyotrophic lateral sclerosis
  • Dopaminergic neurons
  • Gene therapy
  • Motoneurons
  • Parkinson's disease
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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