Glial toll-like receptor signaling in central nervous system infection and autoimmunity

Pamela A. Carpentier, D'Anne S. Duncan, Stephen D Miller*

*Corresponding author for this work

Research output: Contribution to journalReview article

120 Scopus citations

Abstract

Innate immunity in the CNS depends primarily on the functions of glial cells, astrocytes and microglia, which are important for the early control of pathogen replication and direct the recruitment and activation of cells of the adaptive immune system required for pathogen clearance. Efficient immune responses are required for clearance of an invading pathogen, but dysregulation of a pro-inflammatory response in the CNS could lead to the development of autoimmunity. This review summarizes the activation of toll-like receptors (TLRs) expressed on glial cells and the functional outcome of these interactions for CNS health and disease which depends on a delicate balance of the protective and toxic effects of molecules induced in the CNS following TLR ligation.

Original languageEnglish (US)
Pages (from-to)140-147
Number of pages8
JournalBrain, Behavior, and Immunity
Volume22
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Astrocytes
  • Autoimmunity
  • CNS
  • Cytokines
  • Glial cells
  • Innate immunity
  • Microglia
  • Neurotoxicity
  • Toll-like receptors

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

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