Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

Kenneth Aldape, Samirkumar B. Amin, David M. Ashley, Jill S. Barnholtz-Sloan, Amanda J. Bates, Rameen Beroukhim, Christoph Bock, Daniel J. Brat, Elizabeth B. Claus, Joseph F. Costello, John F. de Groot, Gaetano Finocchiaro, Pim J. French, Hui K. Gan, Brent Griffith, Christel C. Herold-Mende, Craig Horbinski, Antonio Iavarone, Steven N. Kalkanis, Konstantina KarabatsouHoon Kim, Mathilde C.M. Kouwenhoven, Kerrie L. McDonald, Hrvoje Miletic, Do Hyun Nam, Ho Keung Ng, Simone P. Niclou, Houtan Noushmehr, D. Ryan Ormond, Laila M. Poisson, Guido Reifenberger, Federico Roncaroli, Jason K. Sa, Peter A.E. Sillevis Smitt, Marion Smits, Camila F. Souza, Ghazaleh Tabatabai, Erwin G. Van Meir, Roel G.W. Verhaak*, Colin Watts, Pieter Wesseling, Adelheid Woehrer, W. K. Alfred Yung, Christine Jungk, Ann Christin Hau, Eric van Dyck, Bart A. Westerman, Julia Yin, Olajide Abiola, Nikolaj Zeps, Sean Grimmond, Michael Buckland, Mustafa Khasraw, Erik P. Sulman, Andrea M. Muscat, Lucy Stead

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities and, ultimately, improved outcomes for a patient population in need.

Original languageEnglish (US)
Pages (from-to)873-884
Number of pages12
Issue number7
StatePublished - Jun 18 2018


  • characterization
  • evolution
  • glioma
  • sequencing
  • subtypes

ASJC Scopus subject areas

  • Clinical Neurology
  • Oncology
  • Cancer Research


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