Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment

Jie Liu; Yong Sheng Zhu; Muhammad Ayaz Khan; Estee Brunk; Kristin Martin-Cook; Myron F. Weiner; C. Munro Cullum; Hanzhang Lu; Benjamin D. Levine; Ramon Diaz-Arrastia; Rong Zhang

doi:10.1016/j.jalz.2013.04.507

Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment

Jie Liu, Yong Sheng Zhu, Muhammad Ayaz Khan, Estee Brunk, Kristin Martin-Cook, Myron F. Weiner, C. Munro Cullum, Hanzhang Lu, Benjamin D. Levine, Ramon Diaz-Arrastia, Rong Zhang^*

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Background To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI). Methods Thirty-two aMCI and 21 normal subjects participated. Total cerebral blood flow (TCBF), cerebral metabolic rate of oxygen (CMRO₂), and brain tissue volume were measured using color-coded duplex ultrasonography (CDUS), near-infrared spectroscopy (NIRS), and MRI. TCBF was normalized by total brain tissue volume (TBV) for group comparisons (nTCBF). Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by TCBF. Results Reductions in nTCBF by 9%, CMRO₂ by 11%, and an increase in CVR by 13% were observed in aMCI relative to normal subjects. No group differences in TBV were observed. nTCBF was correlated with CMRO₂ in normal controls, but not in aMCI. Conclusions Global brain hypoperfusion, oxygen hypometabolism, and neurovascular decoupling observed in aMCI suggest that changes in cerebral hemodynamics occur early at a prodromal stage of Alzheimer's disease, which can be assessed using low-cost and bedside-available CDUS and NIRS technology.

Original language	English (US)
Pages (from-to)	162-170
Number of pages	9
Journal	Alzheimer's and Dementia
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/j.jalz.2013.04.507
State	Published - Mar 2014

Funding

This work was support by National Institutes of Health grant R01AG033106-01 and National Institute of Aging grant P30 AG12300 . Jie Liu conducted the statistical analysis and drafted the manuscript; Jie Liu, Yong-Sheng Zhu, and Muhammad Ayaz Khan performed data acquisition, analysis, and interpretation; Estee Brunk and Kristin Martin-Cook performed subject's screening, cognitive data collection, clinical support, and study coordination; Myron F. Weiner, Ramon Diaz-Arrastia, C. Munro Cullum, and Benjamin D. Levine performed clinical diagnosis and support; Ramon Diaz-Arrastia, Hanzhang Lu, and Rong Zhang were involved in the study concept and experimental design, interpretation of data, and study supervision. All authors edited and revised the manuscript and approved final submission with no conflict of interest to disclose. The authors sincerely thank all of the study participants for their willingness, time, and effort devoted to this study and Mr. Kyle Armstrong, Ms. Rosemary Parker, and all members of the study team for their excellent technical support.

Keywords

Cerebral blood flow
Cerebral metabolic rate of oxygen
MRI
Mild cognitive impairment
Near-infrared spectroscopy
Ultrasonography

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1016/j.jalz.2013.04.507

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@article{8fec8f17ed0c4ad482553148f5cf23bf,

title = "Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment",

abstract = "Background To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI). Methods Thirty-two aMCI and 21 normal subjects participated. Total cerebral blood flow (TCBF), cerebral metabolic rate of oxygen (CMRO2), and brain tissue volume were measured using color-coded duplex ultrasonography (CDUS), near-infrared spectroscopy (NIRS), and MRI. TCBF was normalized by total brain tissue volume (TBV) for group comparisons (nTCBF). Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by TCBF. Results Reductions in nTCBF by 9\%, CMRO2 by 11\%, and an increase in CVR by 13\% were observed in aMCI relative to normal subjects. No group differences in TBV were observed. nTCBF was correlated with CMRO2 in normal controls, but not in aMCI. Conclusions Global brain hypoperfusion, oxygen hypometabolism, and neurovascular decoupling observed in aMCI suggest that changes in cerebral hemodynamics occur early at a prodromal stage of Alzheimer's disease, which can be assessed using low-cost and bedside-available CDUS and NIRS technology.",

keywords = "Cerebral blood flow, Cerebral metabolic rate of oxygen, MRI, Mild cognitive impairment, Near-infrared spectroscopy, Ultrasonography",

author = "Jie Liu and Zhu, \{Yong Sheng\} and Khan, \{Muhammad Ayaz\} and Estee Brunk and Kristin Martin-Cook and Weiner, \{Myron F.\} and Cullum, \{C. Munro\} and Hanzhang Lu and Levine, \{Benjamin D.\} and Ramon Diaz-Arrastia and Rong Zhang",

note = "Funding Information: This work was support by National Institutes of Health grant R01AG033106-01 and National Institute of Aging grant P30 AG12300 . Jie Liu conducted the statistical analysis and drafted the manuscript; Jie Liu, Yong-Sheng Zhu, and Muhammad Ayaz Khan performed data acquisition, analysis, and interpretation; Estee Brunk and Kristin Martin-Cook performed subject's screening, cognitive data collection, clinical support, and study coordination; Myron F. Weiner, Ramon Diaz-Arrastia, C. Munro Cullum, and Benjamin D. Levine performed clinical diagnosis and support; Ramon Diaz-Arrastia, Hanzhang Lu, and Rong Zhang were involved in the study concept and experimental design, interpretation of data, and study supervision. All authors edited and revised the manuscript and approved final submission with no conflict of interest to disclose. The authors sincerely thank all of the study participants for their willingness, time, and effort devoted to this study and Mr. Kyle Armstrong, Ms. Rosemary Parker, and all members of the study team for their excellent technical support.",

year = "2014",

month = mar,

doi = "10.1016/j.jalz.2013.04.507",

language = "English (US)",

volume = "10",

pages = "162--170",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment

AU - Liu, Jie

AU - Zhu, Yong Sheng

AU - Khan, Muhammad Ayaz

AU - Brunk, Estee

AU - Martin-Cook, Kristin

AU - Weiner, Myron F.

AU - Cullum, C. Munro

AU - Lu, Hanzhang

AU - Levine, Benjamin D.

AU - Diaz-Arrastia, Ramon

AU - Zhang, Rong

N1 - Funding Information: This work was support by National Institutes of Health grant R01AG033106-01 and National Institute of Aging grant P30 AG12300 . Jie Liu conducted the statistical analysis and drafted the manuscript; Jie Liu, Yong-Sheng Zhu, and Muhammad Ayaz Khan performed data acquisition, analysis, and interpretation; Estee Brunk and Kristin Martin-Cook performed subject's screening, cognitive data collection, clinical support, and study coordination; Myron F. Weiner, Ramon Diaz-Arrastia, C. Munro Cullum, and Benjamin D. Levine performed clinical diagnosis and support; Ramon Diaz-Arrastia, Hanzhang Lu, and Rong Zhang were involved in the study concept and experimental design, interpretation of data, and study supervision. All authors edited and revised the manuscript and approved final submission with no conflict of interest to disclose. The authors sincerely thank all of the study participants for their willingness, time, and effort devoted to this study and Mr. Kyle Armstrong, Ms. Rosemary Parker, and all members of the study team for their excellent technical support.

PY - 2014/3

Y1 - 2014/3

N2 - Background To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI). Methods Thirty-two aMCI and 21 normal subjects participated. Total cerebral blood flow (TCBF), cerebral metabolic rate of oxygen (CMRO2), and brain tissue volume were measured using color-coded duplex ultrasonography (CDUS), near-infrared spectroscopy (NIRS), and MRI. TCBF was normalized by total brain tissue volume (TBV) for group comparisons (nTCBF). Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by TCBF. Results Reductions in nTCBF by 9%, CMRO2 by 11%, and an increase in CVR by 13% were observed in aMCI relative to normal subjects. No group differences in TBV were observed. nTCBF was correlated with CMRO2 in normal controls, but not in aMCI. Conclusions Global brain hypoperfusion, oxygen hypometabolism, and neurovascular decoupling observed in aMCI suggest that changes in cerebral hemodynamics occur early at a prodromal stage of Alzheimer's disease, which can be assessed using low-cost and bedside-available CDUS and NIRS technology.

AB - Background To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI). Methods Thirty-two aMCI and 21 normal subjects participated. Total cerebral blood flow (TCBF), cerebral metabolic rate of oxygen (CMRO2), and brain tissue volume were measured using color-coded duplex ultrasonography (CDUS), near-infrared spectroscopy (NIRS), and MRI. TCBF was normalized by total brain tissue volume (TBV) for group comparisons (nTCBF). Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by TCBF. Results Reductions in nTCBF by 9%, CMRO2 by 11%, and an increase in CVR by 13% were observed in aMCI relative to normal subjects. No group differences in TBV were observed. nTCBF was correlated with CMRO2 in normal controls, but not in aMCI. Conclusions Global brain hypoperfusion, oxygen hypometabolism, and neurovascular decoupling observed in aMCI suggest that changes in cerebral hemodynamics occur early at a prodromal stage of Alzheimer's disease, which can be assessed using low-cost and bedside-available CDUS and NIRS technology.

KW - Cerebral blood flow

KW - Cerebral metabolic rate of oxygen

KW - MRI

KW - Mild cognitive impairment

KW - Near-infrared spectroscopy

KW - Ultrasonography

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M3 - Article

C2 - 23871763

AN - SCOPUS:84897549756

SN - 1552-5260

VL - 10

SP - 162

EP - 170

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment

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