TY - JOUR
T1 - Global disruption of degree rank order
T2 - A hallmark of chronic pain
AU - Mansour, Ali
AU - Baria, Alex T.
AU - Tetreault, Pascal
AU - Vachon-Presseau, Etienne
AU - Chang, Pei Ching
AU - Huang, Lejian
AU - Apkarian, A. Vania
AU - Baliki, Marwan N.
N1 - Funding Information:
This work was supported by NIH grant NS035115. We thank T. Parrish and D. Procissi for help in human and animal data collection protocols. We thank Apkarian lab members K.H., S.T., M.V.C., B.P. and J.H., as well as T.J.S. for help in data collection, and for suggestions for revising the manuscript.
PY - 2016/10/11
Y1 - 2016/10/11
N2 - Chronic pain remains poorly understood; yet it is associated with the reorganization of the nervous system. Here, we demonstrate that a unitary global measure of functional connectivity, defined as the extent of degree rank order disruption, k D, identifies the chronic pain state. In contrast, local degree disruption differentiates between chronic pain conditions. We used resting-state functional MRI data to analyze the brain connectome at varying scales and densities. In three chronic pain conditions, we observe disrupted k D, in proportion to individuals' pain intensity, and associated with community membership disruption. Additionally, we observe regional degree changes, some of which were unique to each type of chronic pain. Subjects with recent onset of back pain exhibited emergence of k D only when the pain became chronic. Similarly, in neuropathic rats k D emerged weeks after injury, in proportion to pain-like behavior. Thus, we found comprehensive cross-species evidence for chronic pain being a state of global randomization of functional connectivity.
AB - Chronic pain remains poorly understood; yet it is associated with the reorganization of the nervous system. Here, we demonstrate that a unitary global measure of functional connectivity, defined as the extent of degree rank order disruption, k D, identifies the chronic pain state. In contrast, local degree disruption differentiates between chronic pain conditions. We used resting-state functional MRI data to analyze the brain connectome at varying scales and densities. In three chronic pain conditions, we observe disrupted k D, in proportion to individuals' pain intensity, and associated with community membership disruption. Additionally, we observe regional degree changes, some of which were unique to each type of chronic pain. Subjects with recent onset of back pain exhibited emergence of k D only when the pain became chronic. Similarly, in neuropathic rats k D emerged weeks after injury, in proportion to pain-like behavior. Thus, we found comprehensive cross-species evidence for chronic pain being a state of global randomization of functional connectivity.
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U2 - 10.1038/srep34853
DO - 10.1038/srep34853
M3 - Article
C2 - 27725689
AN - SCOPUS:84991101938
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 34853
ER -