Global fiber reconstruction becomes practical

Marco Reisert*, Irina Mader, Constantin Anastasopoulos, Matthias Weigel, Susanne Schnell, Valerij Kiselev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

235 Scopus citations


Global fiber reconstruction aims at providing a consistent view of the fiber architecture in the whole volume of cerebral white matter on the basis of diffusion-sensitized magnetic resonance imaging. A new realization of this principle is presented. The method utilizes data acquired with high angular resolution diffusion imaging (HARDI), a measurement method that fulfills clinical requirements. For the first time among global reconstruction methods, the computation time is acceptable for a broad class of practical applications. The method does not involve any boundary conditions that prescribe the location of the ends of reconstructed fibers. This helps to minimize necessary user interaction and operator dependence. Results obtained in a physical phantom demonstrate a high reconstruction quality. In vivo results have been obtained in several volunteers. The algorithm found a number of prominent fascicles including those in the limbic system, which had been problematic for a previously published version of global tracking.

Original languageEnglish (US)
Pages (from-to)955-962
Number of pages8
Issue number2
StatePublished - Jan 15 2011


  • Diffusion-weighted imaging
  • Global fiber tracking
  • Q-Ball imaging
  • Tractography

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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