Global longitudinal strain predicts left ventricular dysfunction after mitral valve repair

Tomasz G. Witkowski, James D. Thomas, Philippe J M R Debonnaire, Victoria Delgado, Ulas Hoke, See H. Ewe, Michel I M Versteegh, Eduard R. Holman, Martin J. Schalij, Jeroen J. Bax, Robert J M Klautz, Nina Ajmone Marsan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

157 Scopus citations


Aims: Despite a successful surgical procedure and adherence to current recommendations, postoperative left ventricular (LV) dysfunction after mitral valve repair (MVr) for organic mitral regurgitation (MR) may still occur. New approaches are therefore needed to detect subclinical preoperative LV dysfunction. LV global longitudinal strain (GLS), assessed with speckle-tracking echocardiographic analysis, has been proposed as a novel measure to better depict latent LV dysfunction. The aim of this study was to investigate the value of GLS to predict long-term LV dysfunction after MVr. Methods and results: A total of 233 patients (61% men, 61 ± 12 years) with moderate-severe organic MR who underwent successful MVr between 2000 and 2009 were included. Echocardiography was performed at baseline and long-term follow-up (34 ± 20 months) after MVr. LV dysfunction at follow-up was defined as LV ejection fraction (EF) <50% and was present in 29 (12%) patients. A cut-off value of -19.9% of GLS showed a sensitivity and specificity of 90 and 79% to predict long-term LV dysfunction. By univariate logistic regression analysis, baseline LVEF ≤60%, LV end-systolic diameter (ESD) ≥40 mm, atrial fibrillation, presence of symptoms, and GLS >-19.9% were predictors of long-term LV dysfunction. By multivariate analysis, GLS remained an independent predictor of LV dysfunction (odds ratio 23.16, 95% confidence interval: 6.53-82.10, P < 0.001), together with LVESD. Conclusion: In a large series of patients operated within the last decade, MVr resulted in a low incidence of long-term LV dysfunction. A GLS of >-19.9% demonstrated to be a major independent predictor of long-term LV dysfunction after adjustment for parameters currently implemented into guidelines. All rights reserved.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalEuropean heart journal cardiovascular Imaging
Issue number1
StatePublished - Jan 2013


  • Global longitudinal strain
  • Left ventricular function
  • Mitral valve repair
  • Organic mitral regurgitation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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