Glomerular immune complexes associated with cancer

R. R. Pascal, F. M. Rollwagen, M. N. Koss, P. M. Iannaccone

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The occurrence of glomerular immune complex deposits associated with extrarenal malignant tumors has been described in experimental animals and observed in man. Subendothelial deposits containing IgG, β1C, and C type viral particles are present in AKR leukemic mice. Similar deposits, which react with antiserum to mouse mammary tumor virus but do not contain viruses, are found in R III mice with localized mammary tumors. The Ig fraction of eluates of these kidneys also react with antigens of the mouse mammary tumor. Among humans with cancer, glomerular deposits were found in 11 of 23 cases studied by electron microscopy and immunofluorescence. Of these, 6 had lymphoreticular malignancies, 4 had epithelial cancer, and one had a synovial sarcoma. In all cases the deposits were located in the subendothelial region and the mesangium. None of the patients had signs of glomerulonephritis during life. It is postulated that circulating immune complexes containing tumors associated antigens are concentrated in the kidneys of humans and animals with a wide variety of malignancies. These findings have led to further examination of the kidneys from cancer patients in order to characterize the nature of the antigens and antibodies.

Original languageEnglish (US)
Number of pages1
JournalLaboratory Investigation
Issue number3
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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