GluA1 promotes the activity-dependent development of motor circuitry in the developing segmental spinal cord

Angela M. Jablonski; Robert G. Kalb

doi:10.1111/nyas.12053

GluA1 promotes the activity-dependent development of motor circuitry in the developing segmental spinal cord

Angela M. Jablonski, Robert G. Kalb^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The neuronal dendritic tree is a key determinant of how neurons receive, compute, and transmit information. During early postnatal life, synaptic activity promotes dendrite elaboration. Spinal motor neurons utilize GluA1-containing AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptors (AMPA-R) to control this process. This form of developmental dendrite growth can occur independently of N-methyl-d-aspartate receptors (NMDA-R). This review focuses on the mechanism by which the GluA1 subunit of AMPA-R transforms synaptic activity into dendrite growth, and describes the essential role of the GluA1 binding partner SAP97 (synapse-associated protein of 97 kDa molecular weight) in this process. This work defines a new mechanism of activity-dependent development, which might be harnessed to stimulate the recovery of function following insult to the central nervous system.

Original language	English (US)
Pages (from-to)	54-59
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	1279
Issue number	1
DOIs	https://doi.org/10.1111/nyas.12053
State	Published - Apr 2013

Keywords

AMPA
Activity dependent
Dendrite
Development
GluA1
Growth

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/nyas.12053

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abstract = "The neuronal dendritic tree is a key determinant of how neurons receive, compute, and transmit information. During early postnatal life, synaptic activity promotes dendrite elaboration. Spinal motor neurons utilize GluA1-containing AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptors (AMPA-R) to control this process. This form of developmental dendrite growth can occur independently of N-methyl-d-aspartate receptors (NMDA-R). This review focuses on the mechanism by which the GluA1 subunit of AMPA-R transforms synaptic activity into dendrite growth, and describes the essential role of the GluA1 binding partner SAP97 (synapse-associated protein of 97 kDa molecular weight) in this process. This work defines a new mechanism of activity-dependent development, which might be harnessed to stimulate the recovery of function following insult to the central nervous system.",

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